HitPredict

Interactor 1: MCM4 (P33991)
DNA replication licensing factor MCM4 (EC 3.6.4.12) (CDC21 homolog) (P1-CDC21)
Gene: MCM4

Interactor 2: MP2K1 (Q02750)
Dual specificity mitogen-activated protein kinase kinase 1 (MAP kinase kinase 1) (MAPKK 1) (MKK1) (EC 2.7.12.2) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK 1)
Gene: MAP2K1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.54	0.60	0.571

Property	Details
Experiments	31980649, unassigned2173
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005524 - ATP binding GO:0005634 - nucleus
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 863 Hs			1 393
+	Hs
		625167 MCM4_HUMAN (1-863): 0: 952: 100.00		CDK2_HUMAN (65-367): 2.85e-123: 359: 24.27
+	Hs
		708431 MCM4_HUMAN (1-863): 0: 952: 100.00		STK4_HUMAN (37-369): 2.53e-111: 336: 30.06
+	Hs
		414780 MCM4_HUMAN (1-863): 0: 952: 100.00		CDK1_HUMAN (65-367): 7.64e-110: 325: 26.45
+	Hs
		625235 MCM2_HUMAN (2-839): 0: 762: 27.95		CDK2_HUMAN (65-367): 2.85e-123: 359: 24.27
+	Sc
		675511 MCM4_YEAST (1-862): 0: 745: 41.83		HOG1_YEAST (66-393): 1.71e-122: 362: 21.15
+	Sc
		412681 MCM4_YEAST (1-862): 0: 745: 41.83		KAPA_YEAST (2-390): 2.09e-115: 343: 18.69
+	Hs
		414822 MCM2_HUMAN (2-839): 0: 762: 27.95		CDK1_HUMAN (65-367): 7.64e-110: 325: 26.45
+	Hs
		625435 MCM6_HUMAN (138-842): 0: 675: 26.97		CDK2_HUMAN (65-367): 2.85e-123: 359: 24.27
+	Hs
		625168 MCM7_HUMAN (158-841): 0: 660: 29.88		CDK2_HUMAN (65-367): 2.85e-123: 359: 24.27
+	Hs
		708884 MCM7_HUMAN (158-841): 0: 660: 29.88		STK4_HUMAN (37-369): 2.53e-111: 336: 30.06