HitPredict

Interactor 1: MCM5 (P33992)
DNA replication licensing factor MCM5 (EC 3.6.4.12) (CDC46 homolog) (P1-CDC46)
Gene: MCM5

Interactor 2: MCM7 (P33993)
DNA replication licensing factor MCM7 (EC 3.6.4.12) (CDC47 homolog) (P1.1-MCM3)
Gene: MCM7

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.91 1.00 0.959

The method score is based on:

Property Details
Experiments 9099751, 33961781, 23993743, 12614612, 11248027, 15232106, 23764002
Identification Methods affinity chromatography technology, two hybrid, pull down, anti tag coimmunoprecipitation, protein array
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains MCM~MCM, MCM~MCM_lid, MCM~MCM_N, MCM~MCM_OB, MCM_N~MCM_N, MCM_N~MCM_OB, MCM_OB~MCM_OB
Common GO terms GO:0000727 - double-strand break repair via break-induced replication
GO:0000781 - chromosome, telomeric region
GO:0003697 - single-stranded DNA binding
GO:0005524 - ATP binding
GO:0005634 - nucleus
and 11 others

more...
Homologous interactions 19

Homologous interactions

Color coding for hit scores

1 734
Hs

1 719
+ Xl
+ Dm
+ Hs
+ Hs
+ Hs
+ Xl
+ Xl
+ Dm
+ Xl
+ Xl
+ Dm
+ Dm
+ At
+ Xl
+ Hs
+ Xl
+ Xl
+ Xl
+ Sp

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Last updated: 15 Jul 2024