HitPredict

Interactor 1: MCM5 (P33992)
DNA replication licensing factor MCM5 (EC 3.6.4.12) (CDC46 homolog) (P1-CDC46)
Gene: MCM5

Interactor 2: MCM2 (P49736)
DNA replication licensing factor MCM2 (EC 3.6.4.12) (Minichromosome maintenance protein 2 homolog) (Nuclear protein BM28)
Gene: MCM2

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.92 1.00 0.964

The method score is based on:

Property Details
Experiments 25963833, 12614612, 23993743, 11248027, 37071682, 15232106, 17296731, 22540012
Identification Methods affinity chromatography technology, two hybrid, cross-linking study, pull down, protein array, tandem affinity purification, cosedimentation through density gradient
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains MCM~MCM, MCM~MCM_lid, MCM~MCM_N, MCM~MCM_OB, MCM_N~MCM_N, MCM_N~MCM_OB, MCM_OB~MCM_OB
Common GO terms GO:0000727 - double-strand break repair via break-induced replication
GO:0000781 - chromosome, telomeric region
GO:0003688 - DNA replication origin binding
GO:0003697 - single-stranded DNA binding
GO:0005524 - ATP binding
and 11 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 734
Hs

1 904
+ Dm
+ Hs
+ Dm
+ Hs
+ Hs
+ Mm
+ Hs
+ Hs
+ Hs
+ Xl
+ Xl
+ Xl
+ Dm
+ At
+ Xl
+ Xl
+ Xl
+ Xl
+ Xl
+ Sp

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Last updated: 15 Jul 2024