HitPredict

Interactor 1: MCM5 (P33992)
DNA replication licensing factor MCM5 (EC 3.6.4.12) (CDC46 homolog) (P1-CDC46)
Gene: MCM5

Interactor 2: PSF1 (Q14691)
DNA replication complex GINS protein PSF1 (GINS complex subunit 1)
Gene: GINS1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.60	1.00	0.776

Property	Details
Experiments	33961781, 32769987
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	MCM~Sld5, MCM_N~Sld5
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006268 - DNA unwinding involved in DNA replication GO:0071162 - CMG complex
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 734 Hs			1 196
+	Dm
		1366525 MCM5_DROME (1-733): 0: 788: 68.39		Q9W0I7_DROME (1-194): 2.85e-90: 264: 51.53
+	Ce
		1094509 MCM5_CAEEL (1-734): 0: 738: 59.09		PSF1_CAEEL (4-192): 5.91e-78: 233: 40.74
+	Hs
		832463 MCM2_HUMAN (28-732): 0: 675: 30.09		PSF1_HUMAN (1-196): 2.23e-101: 292: 100.00
+	Hs
		708909 MCM7_HUMAN (27-730): 0: 649: 27.57		PSF1_HUMAN (1-196): 2.23e-101: 292: 100.00
+	Ce
		1094587 MCM4_CAEEL (13-732): 0: 634: 28.42		PSF1_CAEEL (4-192): 5.91e-78: 233: 40.74
+	Sc
		667904 MCM5_YEAST (4-732): 0: 674: 46.34		PSF1_YEAST (1-194): 1.26e-58: 184: 26.54
+	Sc
		667656 MCM2_YEAST (29-685): 0: 654: 32.24		PSF1_YEAST (1-194): 1.26e-58: 184: 26.54
+	Sc
		675576 MCM4_YEAST (21-731): 0: 638: 28.69		PSF1_YEAST (1-194): 1.26e-58: 184: 26.54
+	Sc
		859034 MCM6_YEAST (1-713): 0: 629: 25.63		PSF1_YEAST (1-194): 1.26e-58: 184: 26.54
+	Ce
		183740 O16297_CAEEL (95-647): 3.69e-95: 313: 36.32		PSF1_CAEEL (4-192): 5.91e-78: 233: 40.74
+	Ce
		1094591 Q9XVR7_CAEEL (18-647): 7.34e-92: 306: 31.69		PSF1_CAEEL (4-192): 5.91e-78: 233: 40.74
+	Sc
		744800 MCM7_YEAST (132-647): 1.22e-89: 300: 38.00		PSF1_YEAST (1-194): 1.26e-58: 184: 26.54