HitPredict

Interactor 1: EP300 (B2RWS6)
Histone acetyltransferase p300 (p300 HAT) (EC 2.3.1.48) (E1A-associated protein p300) (Histone butyryltransferase p300) (EC 2.3.1.-) (Histone crotonyltransferase p300) (EC 2.3.1.-) (Protein 2-hydroxyisobutyryltransferase p300) (EC 2.3.1.-) (Protein lactyltransferas p300) (EC 2.3.1.-) (Protein propionyltransferase p300) (EC 2.3.1.-)
Gene: EP300

Interactor 2: P53 (P02340)
Cellular tumor antigen p53 (Tumor suppressor p53)
Gene: Tp53

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.87 1.00 0.937

The method score is based on:

Property Details
Experiments 14555661, 22666487, 21057544, 10706102, 9194565, 25117711
Identification Methods pull down, affinity chromatography technology, anti bait coimmunoprecipitation, cross-linking study
Interaction Type direct interaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains Creb_binding~P53_TAD, P53_TAD~zf-TAZ
Common GO terms GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000785 - chromatin
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0001221 - transcription coregulator binding
GO:0001756 - somitogenesis
and 22 others

more...
Homologous interactions 18

Homologous interactions

Color coding for hit scores

1 2412
Mm

1 390
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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024