HitPredict

Interactor 1: MCM7 (P33993)
DNA replication licensing factor MCM7 (EC 3.6.4.12) (CDC47 homolog) (P1.1-MCM3)
Gene: MCM7

Interactor 2: MCM2 (P49736)
DNA replication licensing factor MCM2 (EC 3.6.4.12) (Minichromosome maintenance protein 2 homolog) (Nuclear protein BM28)
Gene: MCM2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.96 1.00 0.981

The method score is based on:

Property Details
Experiments 25963833, 30100344, 17296731, 12694531, 12614612, 10567526, 33961781, 26186194, 27173435, 9099751, 12207017, 15232106, 23764002
Identification Methods affinity chromatography technology, pull down, two hybrid, biochemical, protein array, tandem affinity purification, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains MCM~MCM, MCM~MCM_lid, MCM~MCM_N, MCM~MCM_OB, MCM_N~MCM_N, MCM_N~MCM_OB, MCM_OB~MCM_OB
Common GO terms GO:0000727 - double-strand break repair via break-induced replication
GO:0000781 - chromosome, telomeric region
GO:0000785 - chromatin
GO:0003697 - single-stranded DNA binding
GO:0005524 - ATP binding
and 10 others

more...
Homologous interactions 19

Homologous interactions

Color coding for hit scores

1 719
Hs

1 904
+ Xl
+ Xl
+ Hs
+ Xl
+ Hs
+ Dm
+ Hs
+ Xl
+ Hs
+ Mm
+ Hs
+ Hs
+ Hs
+ Dm
+ Xl
+ Xl
+ Dm
+ At
+ Hs

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Last updated: 15 Jul 2024