HitPredict

Interactor 1: MCM7 (P33993)
DNA replication licensing factor MCM7 (EC 3.6.4.12) (CDC47 homolog) (P1.1-MCM3)
Gene: MCM7

Interactor 2: PSF1 (Q14691)
DNA replication complex GINS protein PSF1 (GINS complex subunit 1)
Gene: GINS1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	1.00	0.811

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	MCM~Sld5, MCM_N~Sld5
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006268 - DNA unwinding involved in DNA replication GO:0071162 - CMG complex
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 719 Hs			1 196
+	Hs
		708646 MCM5_HUMAN (6-716): 0: 682: 27.61		PSF1_HUMAN (1-196): 2.23e-101: 292: 100.00
+	Hs
		832463 MCM2_HUMAN (8-690): 0: 643: 28.13		PSF1_HUMAN (1-196): 2.23e-101: 292: 100.00
+	Ce
		183740 O16297_CAEEL (3-718): 0: 680: 49.24		PSF1_CAEEL (4-192): 5.91e-78: 233: 40.74
+	Dm
		1376134 MCM3_DROME (34-656): 0: 648: 32.99		Q9W0I7_DROME (1-194): 2.85e-90: 264: 51.53
+	Dm
		1366525 MCM5_DROME (5-716): 0: 636: 28.40		Q9W0I7_DROME (1-194): 2.85e-90: 264: 51.53
+	Ce
		1094587 MCM4_CAEEL (7-689): 0: 660: 31.27		PSF1_CAEEL (4-192): 5.91e-78: 233: 40.74
+	Sc
		667904 MCM5_YEAST (5-716): 0: 666: 27.77		PSF1_YEAST (1-194): 1.26e-58: 184: 26.54
+	Sc
		675576 MCM4_YEAST (7-703): 0: 658: 29.69		PSF1_YEAST (1-194): 1.26e-58: 184: 26.54
+	Sc
		744800 MCM7_YEAST (2-719): 0: 643: 45.41		PSF1_YEAST (1-194): 1.26e-58: 184: 26.54
+	Sc
		859034 MCM6_YEAST (9-704): 0: 616: 29.69		PSF1_YEAST (1-194): 1.26e-58: 184: 26.54
+	Ce
		1094591 Q9XVR7_CAEEL (79-640): 4.33e-96: 317: 34.63		PSF1_CAEEL (4-192): 5.91e-78: 233: 40.74