HitPredict

Interactor 1: MCM7 (P33993)
DNA replication licensing factor MCM7 (EC 3.6.4.12) (CDC47 homolog) (P1.1-MCM3)
Gene: MCM7

Interactor 2: SLD5 (Q9BRT9)
DNA replication complex GINS protein SLD5 (GINS complex subunit 4) [Cleaved into: DNA replication complex GINS protein SLD5, N-terminally processed]
Gene: GINS4

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.80	1.00	0.895

Property	Details
Experiments	26186194, 28514442, 33961781, 34195792
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	MCM~Sld5, MCM_N~Sld5
Common GO terms	GO:0000727 - double-strand break repair via break-induced replication GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006268 - DNA unwinding involved in DNA replication GO:0071162 - CMG complex
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 719 Hs			1 223
+	Mm
		1143182 MCM7_MOUSE (1-719): 0: 785: 92.77		SLD5_MOUSE (1-223): 2.1e-91: 269: 87.89
+	Hs
		708751 MCM5_HUMAN (6-716): 0: 682: 27.61		SLD5_HUMAN (1-223): 5.17e-90: 265: 100.00
+	Mm
		956197 MCM2_MOUSE (8-690): 0: 641: 28.13		SLD5_MOUSE (1-223): 2.1e-91: 269: 87.89
+	Hs
		832679 MCM2_HUMAN (8-690): 0: 643: 28.13		SLD5_HUMAN (1-223): 5.17e-90: 265: 100.00
+	Hs
		708503 MCM4_HUMAN (5-700): 0: 636: 31.52		SLD5_HUMAN (1-223): 5.17e-90: 265: 100.00
+	Mm
		956209 MCM6_MOUSE (4-714): 0: 631: 27.86		SLD5_MOUSE (1-223): 2.1e-91: 269: 87.89
+	Hs
		1055616 MCM6_HUMAN (3-715): 0: 623: 28.05		SLD5_HUMAN (1-223): 5.17e-90: 265: 100.00
+	Sc
		667884 MCM5_YEAST (5-716): 0: 666: 27.77		SLD5_YEAST (14-223): 2.88e-67: 210: 20.97
+	Sc
		675553 MCM4_YEAST (7-703): 0: 658: 29.69		SLD5_YEAST (14-223): 2.88e-67: 210: 20.97
+	Dm
		1362003 MCM3_DROME (34-656): 0: 648: 32.99		Q9VBI1_DROME (19-223): 9.24e-68: 209: 39.51
+	Sc
		744790 MCM7_YEAST (2-719): 0: 643: 45.41		SLD5_YEAST (14-223): 2.88e-67: 210: 20.97
+	Dm
		832227 MCM2_DROME (6-688): 0: 640: 28.45		Q9VBI1_DROME (19-223): 9.24e-68: 209: 39.51
+	Dm
		1361990 MCM5_DROME (5-716): 0: 636: 28.40		Q9VBI1_DROME (19-223): 9.24e-68: 209: 39.51
+	Dm
		1099472 MCM4_DROME (5-714): 0: 624: 29.95		Q9VBI1_DROME (19-223): 9.24e-68: 209: 39.51
+	Sc
		859011 MCM6_YEAST (9-704): 0: 616: 29.69		SLD5_YEAST (14-223): 2.88e-67: 210: 20.97