HitPredict

Interactor 1: MCM7 (P33993)
DNA replication licensing factor MCM7 (EC 3.6.4.12) (CDC47 homolog) (P1.1-MCM3)
Gene: MCM7

Interactor 2: HDAC6 (Q9UBN7)
Histone deacetylase 6 (HD6) (EC 3.5.1.98) (Protein deacetylase HDAC6) (EC 3.5.1.-) (Tubulin-lysine deacetylase HDAC6) (EC 3.5.1.-)
Gene: HDAC6

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.80	0.60	0.694

Property	Details
Experiments	26186194, 28514442, 33961781, 23703321
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 719 Hs			1 1215
+	Hs
		708791 MCM5_HUMAN (6-716): 0: 682: 27.61		HDAC6_HUMAN (1-1215): 0: 1435: 100.00
+	Hs
		832757 MCM2_HUMAN (8-690): 0: 643: 28.13		HDAC6_HUMAN (1-1215): 0: 1435: 100.00
+	Hs
		708895 MCM7_HUMAN (1-719): 0: 786: 100.00		HDAC1_HUMAN (478-896): 4.05e-166: 503: 20.09
+	Hs
		708997 MCM7_HUMAN (1-719): 0: 786: 100.00		HDAC2_HUMAN (78-489): 1.04e-157: 481: 21.02
+	Hs
		709115 MCM7_HUMAN (1-719): 0: 786: 100.00		HDAC5_HUMAN (33-471): 3.29e-145: 469: 32.48
+	Hs
		708713 MCM5_HUMAN (6-716): 0: 682: 27.61		HDAC2_HUMAN (78-489): 1.04e-157: 481: 21.02
+	Hs
		708803 MCM5_HUMAN (6-716): 0: 682: 27.61		HDAC5_HUMAN (33-471): 3.29e-145: 469: 32.48
+	Hs
		832626 MCM2_HUMAN (8-690): 0: 643: 28.13		HDA10_HUMAN (85-449): 8.19e-152: 473: 53.53
+	Hs
		832787 MCM2_HUMAN (8-690): 0: 643: 28.13		HDAC5_HUMAN (33-471): 3.29e-145: 469: 32.48
+	Hs
		708547 MCM4_HUMAN (5-700): 0: 636: 31.52		HDAC5_HUMAN (33-471): 3.29e-145: 469: 32.48
+	Hs
		1055661 MCM6_HUMAN (3-715): 0: 623: 28.05		HDAC5_HUMAN (33-471): 3.29e-145: 469: 32.48