HitPredict

Interactor 1: RACB (P34148)
Rho-related protein racB
Gene: RACB

Interactor 2: PAKC (Q55GV3)
Serine/threonine-protein kinase pakC (dPAKc) (EC 2.7.11.1)
Gene: PAKC

Species: Dictyostelium discoideum

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.34	1.00	0.590

Property	Details
Experiments	15483055
Identification Methods	two hybrid
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PBD~Ras, PH~Ras, Pkinase~Ras
Common GO terms	GO:0000281 - mitotic cytokinesis GO:0005737 - cytoplasm GO:0005886 - plasma membrane GO:0007163 - establishment or maintenance of cell polarity
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 195 Dd			1 477
+	Hs
		681775 RAC1_HUMAN (1-195): 5.9e-80: 238: 70.77		AKT1_HUMAN (15-476): 8.6e-138: 406: 19.83
+	Mm
		103566 RAC1_MOUSE (1-195): 5.9e-80: 238: 70.77		G5E884_MOUSE (34-476): 8.53e-127: 381: 35.49
+	Hs
		925244 RAC1_HUMAN (1-195): 5.9e-80: 238: 70.77		PAK1_HUMAN (34-476): 7.09e-126: 378: 36.04
+	Mm
		292040 RAC1_MOUSE (1-195): 5.9e-80: 238: 70.77		PAK1_MOUSE (34-476): 3.26e-124: 374: 36.04
+	Hs
		277602 RAC1_HUMAN (1-195): 5.9e-80: 238: 70.77		PAK3_HUMAN (34-476): 1.88e-123: 373: 34.68
+	Mm
		925809 RAC1_MOUSE (1-195): 5.9e-80: 238: 70.77		PAK2_MOUSE (86-476): 2e-123: 371: 39.59
+	Dm
		776915 RAC1_DROME (1-195): 1.6e-77: 231: 69.23		PAK_DROME (70-476): 3.67e-123: 376: 38.07
+	Hs
		925245 RAC1_HUMAN (1-195): 5.9e-80: 238: 70.77		PAK2_HUMAN (86-476): 1.32e-122: 369: 39.34
+	Hs
		568619 RAC1_HUMAN (1-195): 5.9e-80: 238: 70.77		KAPCA_HUMAN (167-475): 6.71e-123: 364: 20.13
+	Ce
		975572 RAC1_CAEEL (1-195): 8.01e-80: 237: 70.26		PK1_CAEEL (108-476): 3.07e-115: 352: 40.27
+	Dm
		776912 RAC1_DROME (1-195): 1.6e-77: 231: 69.23		Q9VEV1_DROME (165-477): 2.37e-114: 349: 42.86
+	Hs
		925692 RAC1_HUMAN (1-195): 5.9e-80: 238: 70.77		PAK5_HUMAN (191-476): 6.86e-73: 245: 45.65
+	Hs
		330967 RAC1_HUMAN (1-195): 5.9e-80: 238: 70.77		PAK4_HUMAN (191-475): 6.87e-73: 242: 45.11
+	Hs
		925648 RAC1_HUMAN (1-195): 5.9e-80: 238: 70.77		PAK6_HUMAN (191-475): 6.02e-64: 221: 41.96
+	Sp
		963937 CDC42_SCHPO (1-195): 1.8e-77: 231: 63.08		SHK2_SCHPO (16-179): 2.49e-32: 131: 26.90
+	Dd
		332055 RACF1_DICDI (1-195): 5.65e-87: 255: 63.08		PAKB_DICDI (111-168): 2.32e-09: 61.8: 48.28
+	Dd
		710117 RAC1B_DICDI (1-195): 2.29e-79: 236: 67.18		PAKB_DICDI (111-168): 2.32e-09: 61.8: 48.28
+	Dd
		710116 RAC1A_DICDI (1-195): 5.56e-79: 235: 69.23		PAKB_DICDI (111-168): 2.32e-09: 61.8: 48.28
+	Dd
		710121 RACB_DICDI (1-195): 1.22e-77: 232: 100.00		PAKB_DICDI (111-168): 2.32e-09: 61.8: 48.28
+	Dd
		710118 RAC1C_DICDI (1-195): 1.72e-77: 231: 71.28		PAKB_DICDI (111-168): 2.32e-09: 61.8: 48.28