HitPredict

Interactor 1: FAK1 (P34152)
Focal adhesion kinase 1 (FADK 1) (EC 2.7.10.2) (Focal adhesion kinase-related nonkinase) (FRNK) (Protein-tyrosine kinase 2) (p125FAK) (pp125FAK)
Gene: Ptk2

Interactor 2: DLG4 (Q62108)
Disks large homolog 4 (Postsynaptic density protein 95) (PSD-95) (Synapse-associated protein 90) (SAP-90) (SAP90)
Gene: DLG4

Species: Mus musculus

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	28671696
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH3_1
Common GO terms	GO:0016323 - basolateral plasma membrane GO:0043197 - dendritic spine GO:0044877 - protein-containing complex binding GO:0050806 - positive regulation of synaptic transmission GO:0098794 - postsynapse and 1 others more... GO:0098978 - glutamatergic synapse
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1052 Mm			1 724
+	Hs
		942340 FAK2_HUMAN (35-1042): 0: 773: 44.76		DLG4_HUMAN (1-724): 0: 671: 99.59
+	Hs
		1052831 FAK2_HUMAN (35-1042): 0: 773: 44.76		DLG3_HUMAN (28-724): 0: 600: 64.92
+	Hs
		412128 FYN_HUMAN (225-689): 1.54e-131: 411: 25.73		DLG4_HUMAN (1-724): 0: 671: 99.59
+	Mm
		1142638 ERBB4_MOUSE (404-921): 3.73e-120: 401: 26.20		DLG4_MOUSE (1-724): 0: 671: 100.00
+	Hs
		942346 ERBB4_HUMAN (404-921): 3.08e-118: 396: 25.49		DLG4_HUMAN (1-724): 0: 671: 99.59
+	Hs
		383736 ERBB2_HUMAN (319-926): 5.45e-117: 392: 24.23		DLG4_HUMAN (1-724): 0: 671: 99.59
+	Hs
		872433 EPHA5_HUMAN (154-757): 1.51e-147: 469: 24.43		DLG1_HUMAN (28-724): 0: 576: 72.79
+	Hs
		872639 EPHA4_HUMAN (154-784): 1.18e-140: 449: 23.57		DLG1_HUMAN (28-724): 0: 576: 72.79
+	Hs
		1021499 EPHA7_HUMAN (155-784): 2.33e-140: 448: 22.41		DLG1_HUMAN (28-724): 0: 576: 72.79
+	Hs
		1070994 ERBB4_HUMAN (404-921): 3.08e-118: 396: 25.49		DLG3_HUMAN (28-724): 0: 600: 64.92
+	Mm
		796509 ZAP70_MOUSE (157-699): 7.5e-127: 401: 24.82		DLG1_MOUSE (8-724): 0: 577: 68.93
+	Hs
		1021496 ERBB4_HUMAN (404-921): 3.08e-118: 396: 25.49		DLG1_HUMAN (28-724): 0: 576: 72.79
+	Hs
		1049958 EPHA7_HUMAN (155-784): 2.33e-140: 448: 22.41		SCRIB_HUMAN (58-243): 7.53e-25: 113: 40.72
+	Hs
		159179 EPHA4_HUMAN (154-784): 1.18e-140: 449: 23.57		CSKP_HUMAN (6-381): 1.53e-20: 99: 14.43
+	Hs
		159214 EPHA7_HUMAN (155-784): 2.33e-140: 448: 22.41		CSKP_HUMAN (6-381): 1.53e-20: 99: 14.43
+	Hs
		665600 EPHB2_HUMAN (155-756): 2.59e-130: 423: 23.48		SCRIB_HUMAN (58-243): 7.53e-25: 113: 40.72
+	Hs
		1072518 EPHA7_HUMAN (155-784): 2.33e-140: 448: 22.41		MPP7_HUMAN (51-193): 7.87e-16: 83.2: 16.08
+	Hs
		159139 HCK_HUMAN (160-691): 8.93e-131: 408: 24.58		CSKP_HUMAN (6-381): 1.53e-20: 99: 14.43
+	Hs
		647929 MARK3_HUMAN (367-1043): 7.07e-131: 416: 16.81		DLG5_HUMAN (40-245): 4.01e-17: 88.6: 31.55
+	Hs
		1070968 ERBB4_HUMAN (404-921): 3.08e-118: 396: 25.49		DLG2_HUMAN (234-580): 8.36e-18: 90.1: 19.55