HitPredict

Interactor 1: HCP3L (P34440)
Histone H3-like centromeric protein cpar-1 (CENP-A-related protein 1) (Centromeric protein A related)
Gene: cpar-1

Interactor 2: H4 (P62784)
Histone H4
Gene: his-1

Species: Caenorhabditis elegans

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.55	1.00	0.743

Property	Details
Experiments	18692475, unassigned701
Identification Methods	two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	CENP-T_C~Histone
Common GO terms	GO:0000786 - nucleosome GO:0003677 - DNA binding GO:0005634 - nucleus GO:0030527 - structural constituent of chromatin GO:0046982 - protein heterodimerization activity
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 261 Ce			1 103
+	Hs
		917093 H31_HUMAN (122-256): 7.14e-60: 187: 41.48		H4_HUMAN (1-103): 3.12e-48: 150: 99.03
+	Mm
		918236 H31_MOUSE (122-256): 7.14e-60: 187: 41.48		H4_MOUSE (1-103): 3.12e-48: 150: 99.03
+	Ce
		445733 H3_CAEEL (122-256): 2.35e-58: 183: 41.48		H4_CAEEL (1-103): 7.75e-49: 152: 100.00
+	Xl
		917054 H32_XENLA (122-256): 1.37e-58: 184: 42.22		H4_XENLA (1-103): 3.12e-48: 150: 99.03
+	Xl
		917056 Q92133_XENLA (122-256): 1.43e-58: 184: 42.22		H4_XENLA (1-103): 3.12e-48: 150: 99.03
+	Hs
		917112 H33_HUMAN (122-256): 1.01e-58: 184: 42.22		H4_HUMAN (1-103): 3.12e-48: 150: 99.03
+	Hs
		917483 H32_HUMAN (122-256): 1.37e-58: 184: 42.22		H4_HUMAN (1-103): 3.12e-48: 150: 99.03
+	Mm
		918239 H32_MOUSE (122-256): 1.37e-58: 184: 42.22		H4_MOUSE (1-103): 3.12e-48: 150: 99.03
+	Mm
		918240 H33_MOUSE (122-256): 1.01e-58: 184: 42.22		H4_MOUSE (1-103): 3.12e-48: 150: 99.03
+	Hs
		917352 H31T_HUMAN (122-256): 2.93e-58: 183: 40.00		H4_HUMAN (1-103): 3.12e-48: 150: 99.03
+	Hs
		917448 H3C_HUMAN (122-256): 2.86e-56: 178: 40.74		H4_HUMAN (1-103): 3.12e-48: 150: 99.03
+	Sp
		448920 H31_SCHPO (122-256): 2.3e-56: 178: 43.70		H4_SCHPO (18-103): 1.08e-41: 133: 88.37
+	Hs
		1174638 H32_HUMAN (122-256): 1.37e-58: 184: 42.22		H4G_HUMAN (1-98): 2.86e-38: 125: 83.67
+	Hs
		828186 CENPA_HUMAN (127-256): 4.71e-48: 157: 35.61		H4_HUMAN (1-103): 3.12e-48: 150: 99.03
+	Sc
		356652 H3_YEAST (122-256): 6.88e-53: 169: 40.00		H4_YEAST (18-103): 1.48e-40: 131: 89.54
+	Sc
		356401 CENPA_YEAST (136-256): 1.35e-45: 154: 44.09		H4_YEAST (18-103): 1.48e-40: 131: 89.54
+	Kl
		1150023 CENPA_KLULA (152-256): 4.94e-44: 148: 51.40		Q6CMU6_KLULA (18-103): 2.24e-41: 133: 90.70