HitPredict

Interactor 1: CDK1 (P34556)
Cyclin-dependent kinase 1 (CDK1) (EC 2.7.11.22) (EC 2.7.11.23) (Cell division control protein 2 homolog) (Cell division protein kinase 1) (p34 protein kinase)
Gene: cdk-1

Interactor 2: CKS1 (Q17868)
Cyclin-dependent kinases regulatory subunit
Gene: cks-1

Species: Caenorhabditis elegans

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.67	1.00	0.822

Property	Details
Experiments	16343905, 18692475, unassigned701
Identification Methods	affinity chromatography technology, two hybrid
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	CKS~Pkinase
Common GO terms	GO:0005634 - nucleus GO:0019901 - protein kinase binding GO:0051301 - cell division
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 332 Ce			1 94
+	Hs
		625283 CDK2_HUMAN (19-318): 2.56e-145: 413: 60.00		CKS1_HUMAN (4-81): 3.39e-43: 136: 62.82
+	Hs
		625164 CDK2_HUMAN (19-318): 2.56e-145: 413: 60.00		CKS2_HUMAN (4-81): 3.15e-42: 134: 57.69
+	Hs
		895413 CDK3_HUMAN (19-319): 6.62e-142: 404: 62.46		CKS1_HUMAN (4-81): 3.39e-43: 136: 62.82
+	Hs
		706796 CDK3_HUMAN (19-319): 6.62e-142: 404: 62.46		CKS2_HUMAN (4-81): 3.15e-42: 134: 57.69
+	Hs
		414843 CDK1_HUMAN (19-316): 1.29e-137: 393: 64.77		CKS1_HUMAN (4-81): 3.39e-43: 136: 62.82
+	Hs
		414778 CDK1_HUMAN (19-316): 1.29e-137: 393: 64.77		CKS2_HUMAN (4-81): 3.15e-42: 134: 57.69
+	At
		621728 CDKA1_ARATH (19-315): 2.45e-134: 385: 57.05		CKS2_ARATH (7-85): 2e-42: 134: 55.70
+	At
		1103378 CKB12_ARATH (19-320): 6.78e-133: 382: 45.14		CKS2_ARATH (7-85): 2e-42: 134: 55.70
+	At
		188136 CDKA1_ARATH (19-315): 2.45e-134: 385: 57.05		CKS1_ARATH (7-75): 1.22e-40: 130: 62.32
+	Dm
		618387 CDK1_DROME (19-315): 1.96e-134: 385: 64.65		CKS1_DROME (5-74): 2.86e-40: 128: 62.86
+	Dm
		618415 CDK1_DROME (19-315): 1.96e-134: 385: 64.65		Q9VHN1_DROME (6-73): 1.31e-39: 128: 63.24
+	At
		188147 CKB12_ARATH (19-320): 6.78e-133: 382: 45.14		CKS1_ARATH (7-75): 1.22e-40: 130: 62.32
+	Hs
		895414 CDK5_HUMAN (19-318): 9.28e-131: 376: 50.50		CKS1_HUMAN (4-81): 3.39e-43: 136: 62.82
+	At
		1227962 CKB21_ARATH (16-318): 1.49e-130: 376: 44.05		CKS2_ARATH (7-85): 2e-42: 134: 55.70
+	Hs
		706797 CDK5_HUMAN (19-318): 9.28e-131: 376: 50.50		CKS2_HUMAN (4-81): 3.15e-42: 134: 57.69
+	At
		1321252 CDKD2_ARATH (9-321): 7.67e-129: 373: 41.53		CKS2_ARATH (7-85): 2e-42: 134: 55.70
+	At
		188156 CKB21_ARATH (16-318): 1.49e-130: 376: 44.05		CKS1_ARATH (7-75): 1.22e-40: 130: 62.32
+	At
		188157 CKB22_ARATH (16-318): 1.88e-129: 373: 45.98		CKS1_ARATH (7-75): 1.22e-40: 130: 62.32
+	At
		188163 CDKD2_ARATH (9-321): 7.67e-129: 373: 41.53		CKS1_ARATH (7-75): 1.22e-40: 130: 62.32
+	Sp
		383445 CDK1_SCHPO (19-316): 3.19e-130: 375: 52.96		CKS1_SCHPO (6-83): 1.14e-36: 121: 42.86