HitPredict

Interactor 1: RUXF (P34659)
Probable small nuclear ribonucleoprotein F (snRNP-F) (Sm protein F) (Sm-F) (SmF)
Gene: snr-5

Interactor 2: SMD2 (Q18786)
Probable small nuclear ribonucleoprotein Sm D2 (Sm-D2) (snRNP core protein D2)
Gene: snr-4

Species: Caenorhabditis elegans

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.75	1.00	0.867

Property	Details
Experiments	19123269, 14704431, 11731503
Identification Methods	two hybrid, two hybrid array, two hybrid pooling approach
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	LSM~LSM
Common GO terms	GO:0000387 - spliceosomal snRNP assembly GO:0003723 - RNA binding GO:0005685 - U1 snRNP GO:0005829 - cytosol GO:0034715 - pICln-Sm protein complex and 1 others more... GO:0071013 - catalytic step 2 spliceosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 85 Ce			1 118
+	Dm
		1367655 Q9VKW8_DROME (7-82): 3.83e-34: 115: 27.27		SMD2_DROME (3-117): 1.4e-43: 140: 82.61
+	Dm
		1097027 RUXF_DROME (1-84): 2.03e-34: 114: 65.48		SMD2_DROME (3-117): 1.4e-43: 140: 82.61
+	Hs
		912602 LSM4_HUMAN (7-82): 4.6e-34: 114: 25.97		SMD2_HUMAN (1-114): 3.58e-42: 136: 81.58
+	Hs
		911794 RUXF_HUMAN (5-77): 1.12e-31: 107: 73.97		SMD2_HUMAN (1-114): 3.58e-42: 136: 81.58
+	Hs
		912218 LSM6_HUMAN (8-78): 5.07e-30: 103: 42.25		SMD2_HUMAN (1-114): 3.58e-42: 136: 81.58
+	Dm
		1367661 Q9W2P5_DROME (11-78): 2.12e-27: 96.5: 41.18		SMD2_DROME (3-117): 1.4e-43: 140: 82.61
+	Hs
		912211 LSM4_HUMAN (7-82): 4.6e-34: 114: 25.97		LSM3_HUMAN (13-112): 2e-35: 119: 28.00
+	Hs
		911791 RUXF_HUMAN (5-77): 1.12e-31: 107: 73.97		LSM3_HUMAN (13-112): 2e-35: 119: 28.00
+	Dm
		1213197 Q9VKW8_DROME (7-82): 3.83e-34: 115: 27.27		Q8IMX8_DROME (13-112): 1.39e-31: 109: 33.66
+	Hs
		912417 SMD3_HUMAN (1-78): 1.65e-23: 88: 23.08		SMD2_HUMAN (1-114): 3.58e-42: 136: 81.58
+	Dm
		218370 SMD3_DROME (1-78): 1.21e-21: 83.8: 23.08		SMD2_DROME (3-117): 1.4e-43: 140: 82.61
+	Hs
		912139 LSM6_HUMAN (8-78): 5.07e-30: 103: 42.25		LSM3_HUMAN (13-112): 2e-35: 119: 28.00
+	Hs
		912596 LSM2_HUMAN (11-83): 1.36e-21: 82.3: 31.58		SMD2_HUMAN (1-114): 3.58e-42: 136: 81.58
+	Sc
		873667 RUXF_YEAST (1-79): 4.56e-28: 98.4: 56.25		SMD2_YEAST (1-114): 2.73e-33: 113: 50.00
+	Sp
		223544 RUXF_SCHPO (5-76): 3.34e-29: 100: 69.44		LSM3_SCHPO (19-112): 8.04e-31: 107: 30.85
+	Hs
		912142 SMD3_HUMAN (1-78): 1.65e-23: 88: 23.08		LSM3_HUMAN (13-112): 2e-35: 119: 28.00
+	Dm
		1213201 Q9W2P5_DROME (11-78): 2.12e-27: 96.5: 41.18		Q8IMX8_DROME (13-112): 1.39e-31: 109: 33.66
+	Hs
		912205 LSM2_HUMAN (11-83): 1.36e-21: 82.3: 31.58		LSM3_HUMAN (13-112): 2e-35: 119: 28.00
+	Sc
		795423 SMD3_YEAST (9-78): 1.84e-23: 87.3: 25.71		SMD2_YEAST (1-114): 2.73e-33: 113: 50.00
+	Sc
		795403 SMD3_YEAST (9-78): 1.84e-23: 87.3: 25.71		LSM3_YEAST (28-112): 2.46e-23: 87.9: 28.24