HitPredict

Interactor 1: RYK (P34925)
Tyrosine-protein kinase RYK (EC 2.7.10.1)
Gene: RYK

Interactor 2: DSC2 (Q02487)
Desmocollin-2 (Cadherin family member 2) (Desmocollin-3) (Desmosomal glycoprotein II) (Desmosomal glycoprotein III)
Gene: DSC2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	35384245, 21875946
Identification Methods	proximity labelling technology, affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 607 Hs			1 901
+	Hs
		508000 FGFR1_HUMAN (137-599): 4.53e-145: 441: 27.29		DSC3_HUMAN (1-901): 0: 806: 66.70
+	Hs
		713804 RYK_HUMAN (1-607): 1.73e-146: 438: 100.00		DSC3_HUMAN (1-901): 0: 806: 66.70
+	Hs
		507817 FGFR1_HUMAN (137-599): 4.53e-145: 441: 27.29		CADH1_HUMAN (28-897): 0: 714: 28.09
+	Hs
		713896 RYK_HUMAN (1-607): 1.73e-146: 438: 100.00		PCDGH_HUMAN (1-464): 7.02e-94: 318: 16.74
+	Hs
		231356 RYK_HUMAN (1-607): 1.73e-146: 438: 100.00		PCDGC_HUMAN (1-464): 3.36e-88: 303: 19.55
+	Hs
		713899 RYK_HUMAN (1-607): 1.73e-146: 438: 100.00		PCDG5_HUMAN (1-464): 8.24e-87: 299: 18.65
+	Hs
		713898 RYK_HUMAN (1-607): 1.73e-146: 438: 100.00		PCDG6_HUMAN (1-464): 4.21e-86: 297: 17.92
+	Hs
		713897 RYK_HUMAN (1-607): 1.73e-146: 438: 100.00		PCDG7_HUMAN (1-464): 5.52e-86: 296: 17.62
+	Hs
		713900 RYK_HUMAN (1-607): 1.73e-146: 438: 100.00		PCDGB_HUMAN (6-464): 1.63e-83: 290: 18.52
+	Hs
		507842 FGFR1_HUMAN (137-599): 4.53e-145: 441: 27.29		CADH2_HUMAN (4-385): 1.04e-51: 197: 15.55
+	Hs
		580205 RYK_HUMAN (1-607): 1.73e-146: 438: 100.00		CADH2_HUMAN (4-385): 1.04e-51: 197: 15.55
+	Hs
		508295 FGFR1_HUMAN (137-599): 4.53e-145: 441: 27.29		PCDA8_HUMAN (358-864): 2.34e-50: 193: 13.02
+	Hs
		713894 RYK_HUMAN (1-607): 1.73e-146: 438: 100.00		PCDB2_HUMAN (405-873): 2.71e-51: 195: 15.94
+	Hs
		507929 FGFR1_HUMAN (137-599): 4.53e-145: 441: 27.29		CAD11_HUMAN (4-349): 8.21e-46: 178: 18.78
+	Hs
		580237 NTRK3_HUMAN (61-607): 7.76e-137: 420: 21.92		CADH2_HUMAN (4-385): 1.04e-51: 197: 15.55
+	Xl
		292719 FGFR1_XENLA (137-601): 2.66e-139: 426: 26.10		O93264_XENLA (4-345): 2.86e-43: 171: 19.07
+	Hs
		713831 RYK_HUMAN (1-607): 1.73e-146: 438: 100.00		DSG4_HUMAN (20-372): 1.22e-32: 138: 17.84
+	Hs
		507992 FGFR1_HUMAN (137-599): 4.53e-145: 441: 27.29		DSG2_HUMAN (69-401): 2e-20: 99.3: 17.18
+	Hs
		713802 RYK_HUMAN (1-607): 1.73e-146: 438: 100.00		DSG2_HUMAN (69-401): 2e-20: 99.3: 17.18
+	Hs
		1048593 NTRK3_HUMAN (61-607): 7.76e-137: 420: 21.92		DSG2_HUMAN (69-401): 2e-20: 99.3: 17.18