HitPredict

Interactor 1: RYK (P34925)
Tyrosine-protein kinase RYK (EC 2.7.10.1)
Gene: RYK

Interactor 2: AGRA2 (Q96PE1)
Adhesion G protein-coupled receptor A2 (G-protein coupled receptor 124) (Tumor endothelial marker 5)
Gene: ADGRA2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.62	1.00	0.789

Property	Details
Experiments	33961781, 21875946
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	LRR_8~PK_Tyr_Ser-Thr
Common GO terms	GO:0005886 - plasma membrane GO:0016020 - membrane GO:0060070 - canonical Wnt signaling pathway
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 607 Hs			1 1338
+	Hs
		713834 RYK_HUMAN (1-607): 1.73e-146: 438: 100.00		AGRA3_HUMAN (46-1338): 0: 644: 41.50
+	Hs
		713880 RYK_HUMAN (1-607): 1.73e-146: 438: 100.00		CELR1_HUMAN (260-1325): 5.88e-114: 398: 15.31
+	Hs
		713873 RYK_HUMAN (1-607): 1.73e-146: 438: 100.00		CELR2_HUMAN (266-1326): 1.09e-108: 382: 14.85
+	Hs
		315834 NTRK2_HUMAN (36-607): 8.19e-131: 404: 22.24		AGRL2_HUMAN (363-1184): 8.19e-111: 384: 16.61
+	Hs
		713881 RYK_HUMAN (1-607): 1.73e-146: 438: 100.00		CELR3_HUMAN (329-1309): 3.58e-96: 344: 16.41
+	At
		84475 NIK2_ARATH (4-597): 7.6e-151: 450: 15.15		GSO1_ARATH (1-805): 2.55e-86: 309: 10.92
+	At
		84467 SRF8_ARATH (2-601): 1.35e-148: 447: 14.94		GSO1_ARATH (1-805): 2.55e-86: 309: 10.92
+	At
		84454 Y5457_ARATH (40-606): 9.38e-144: 431: 15.57		GSO1_ARATH (1-805): 2.55e-86: 309: 10.92
+	At
		84471 Q8GX94_ARATH (6-605): 1.14e-137: 415: 14.47		GSO1_ARATH (1-805): 2.55e-86: 309: 10.92
+	At
		84488 NIK1_ARATH (69-597): 6.46e-135: 409: 17.00		GSO1_ARATH (1-805): 2.55e-86: 309: 10.92
+	At
		1209294 Q8GX94_ARATH (6-605): 1.14e-137: 415: 14.47		FLS2_ARATH (27-704): 2.08e-72: 266: 10.71
+	At
		1013322 Y2239_ARATH (68-597): 4.04e-145: 435: 16.64		PEPR2_ARATH (1-569): 4.21e-64: 240: 10.79
+	At
		1324070 NIK1_ARATH (69-597): 6.46e-135: 409: 17.00		FLS2_ARATH (27-704): 2.08e-72: 266: 10.71
+	At
		85032 Y5457_ARATH (40-606): 9.38e-144: 431: 15.57		PEPR2_ARATH (1-569): 4.21e-64: 240: 10.79
+	At
		1209303 Q8GX94_ARATH (6-605): 1.14e-137: 415: 14.47		PEPR2_ARATH (1-569): 4.21e-64: 240: 10.79
+	At
		1013325 Y2239_ARATH (68-597): 4.04e-145: 435: 16.64		Y1571_ARATH (1-551): 5.45e-57: 218: 10.95
+	At
		85038 Y5457_ARATH (40-606): 9.38e-144: 431: 15.57		Y1571_ARATH (1-551): 5.45e-57: 218: 10.95
+	Hs
		713878 RYK_HUMAN (1-607): 1.73e-146: 438: 100.00		LRC4B_HUMAN (7-189): 1.52e-42: 169: 28.43
+	Dr
		60113 A4QN31_DANRE (130-601): 3.11e-138: 421: 26.90		B8JKM0_DANRE (8-182): 2.69e-13: 76.3: 33.71
+	Dr
		82308 FGFR4_DANRE (137-604): 2.21e-135: 419: 23.38		B8JKM0_DANRE (8-182): 2.69e-13: 76.3: 33.71