HitPredict

Interactor 1: RYK (P34925)
Tyrosine-protein kinase RYK (EC 2.7.10.1)
Gene: RYK

Interactor 2: CELR1 (Q9NYQ6)
Cadherin EGF LAG seven-pass G-type receptor 1 (Cadherin family member 9) (Flamingo homolog 2) (hFmi2)
Gene: CELSR1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	33961781, 21875946
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0016020 - membrane GO:0060071 - Wnt signaling pathway, planar cell polarity pathway
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 607 Hs			1 3014
+	Mm
		546312 NTRK2_MOUSE (15-607): 2.45e-130: 403: 22.33		AGRB3_MOUSE (1851-2803): 0: 649: 20.75
+	Hs
		713871 RYK_HUMAN (1-607): 1.73e-146: 438: 100.00		PCDH9_HUMAN (222-786): 2.77e-130: 446: 28.33
+	Hs
		713898 RYK_HUMAN (1-607): 1.73e-146: 438: 100.00		PCDG6_HUMAN (1-557): 1.11e-105: 365: 18.44
+	Hs
		713862 RYK_HUMAN (1-607): 1.73e-146: 438: 100.00		PCD16_HUMAN (1-556): 7.07e-98: 357: 18.75
+	Hs
		713873 RYK_HUMAN (1-607): 1.73e-146: 438: 100.00		CELR2_HUMAN (1-557): 3.48e-96: 351: 20.11
+	Hs
		385795 NTRK1_HUMAN (122-607): 2.22e-129: 400: 25.65		PCDB3_HUMAN (1-557): 1.05e-99: 343: 17.80
+	Hs
		713897 RYK_HUMAN (1-607): 1.73e-146: 438: 100.00		PCDG7_HUMAN (11-452): 1.42e-71: 263: 18.72
+	Hs
		231356 RYK_HUMAN (1-607): 1.73e-146: 438: 100.00		PCDGC_HUMAN (3-452): 1.15e-68: 254: 18.44
+	Hs
		523158 SRC_HUMAN (315-602): 2.06e-108: 338: 30.80		CELR2_HUMAN (1-557): 3.48e-96: 351: 20.11
+	Hs
		433517 YES_HUMAN (315-602): 3.09e-108: 337: 31.14		PCDB3_HUMAN (1-557): 1.05e-99: 343: 17.80
+	Hs
		713790 RYK_HUMAN (1-607): 1.73e-146: 438: 100.00		PCDH1_HUMAN (244-783): 1.44e-58: 224: 31.69
+	Hs
		315834 NTRK2_HUMAN (36-607): 8.19e-131: 404: 22.24		AGRL2_HUMAN (2055-2710): 2.15e-67: 255: 27.89
+	Hs
		315792 NTRK1_HUMAN (122-607): 2.22e-129: 400: 25.65		AGRL2_HUMAN (2055-2710): 2.15e-67: 255: 27.89
+	Hs
		713899 RYK_HUMAN (1-607): 1.73e-146: 438: 100.00		PCDG5_HUMAN (932-1184): 1.31e-35: 150: 25.91
+	Hs
		713894 RYK_HUMAN (1-607): 1.73e-146: 438: 100.00		PCDB2_HUMAN (898-1210): 2.68e-33: 142: 20.24
+	Hs
		713881 RYK_HUMAN (1-607): 1.73e-146: 438: 100.00		CELR3_HUMAN (1-302): 9.07e-18: 93.5: 8.53
+	Hs
		713825 RYK_HUMAN (1-607): 1.73e-146: 438: 100.00		FAT4_HUMAN (2019-2154): 7.82e-14: 80.8: 13.48
+	Hs
		713850 RYK_HUMAN (1-607): 1.73e-146: 438: 100.00		FAT3_HUMAN (1960-2068): 1.59e-10: 69.6: 16.52
+	Hs
		523229 SRC_HUMAN (315-602): 2.06e-108: 338: 30.80		PCDG5_HUMAN (932-1184): 1.31e-35: 150: 25.91
+	Hs
		411385 INSR_HUMAN (237-598): 1.43e-108: 357: 29.40		FAT1_HUMAN (2035-2185): 6.71e-16: 87.3: 10.63