HitPredict

Interactor 1: HSP74 (P34932)
Heat shock 70 kDa protein 4 (HSP70RY) (Heat shock 70-related protein APG-2) (Heat shock protein family H member 2)
Gene: HSPA4

Interactor 2: MT21A (Q8WXB1)
Protein N-lysine methyltransferase METTL21A (EC 2.1.1.-) (HSPA lysine methyltransferase) (HSPA-KMT) (Hepatocellular carcinoma-associated antigen 557b) (Methyltransferase-like protein 21A)
Gene: METTL21A

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.80	0.60	0.694

Property	Details
Experiments	26186194, 28514442, 33961781, 23349634
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 840 Hs			1 218
+	Hs
		320887 HS74L_HUMAN (1-840): 0: 959: 63.21		MT21A_HUMAN (1-218): 2.1e-77: 233: 100.00
+	Hs
		1263328 HS105_HUMAN (1-840): 0: 938: 62.95		MT21A_HUMAN (1-218): 2.1e-77: 233: 100.00
+	Hs
		316475 HSP74_HUMAN (1-840): 0: 993: 100.00		MET18_HUMAN (8-189): 1.88e-33: 125: 19.72
+	Hs
		714382 HSP74_HUMAN (1-840): 0: 993: 100.00		ANM1_HUMAN (57-208): 1.75e-33: 125: 16.03
+	Hs
		320903 HS74L_HUMAN (1-840): 0: 959: 63.21		ANM1_HUMAN (57-208): 1.75e-33: 125: 16.03
+	Zm
		20828 A0A1D6LZY7_MAIZE (1-832): 0: 892: 38.18		A0A1D6HPM6_MAIZE (19-214): 1.23e-55: 180: 27.40
+	Hs
		1267738 HS105_HUMAN (1-840): 0: 938: 62.95		ANM1_HUMAN (57-208): 1.75e-33: 125: 16.03
+	Sp
		142084 HSP7F_SCHPO (2-694): 6.13e-162: 490: 42.39		ANM3_SCHPO (55-194): 6.74e-36: 133: 17.93
+	Hs
		504476 HSP7C_HUMAN (564-692): 5.97e-20: 97: 16.92		MT21A_HUMAN (1-218): 2.1e-77: 233: 100.00
+	Hs
		483797 HS71B_HUMAN (571-686): 1.59e-19: 95.5: 23.93		MT21A_HUMAN (1-218): 2.1e-77: 233: 100.00
+	Hs
		714031 HS71L_HUMAN (564-691): 7.22e-19: 93.5: 22.48		MT21A_HUMAN (1-218): 2.1e-77: 233: 100.00
+	Hs
		504537 HSP7C_HUMAN (564-692): 5.97e-20: 97: 16.92		EFMT3_HUMAN (13-216): 3.92e-64: 200: 42.51
+	Hs
		714042 HS71L_HUMAN (564-691): 7.22e-19: 93.5: 22.48		EFMT3_HUMAN (13-216): 3.92e-64: 200: 42.51
+	Hs
		504229 HSP7C_HUMAN (564-692): 5.97e-20: 97: 16.92		MT21C_HUMAN (21-212): 2.38e-55: 179: 31.98
+	Hs
		713993 HS71L_HUMAN (564-691): 7.22e-19: 93.5: 22.48		MT21C_HUMAN (21-212): 2.38e-55: 179: 31.98
+	Hs
		504315 HSP7C_HUMAN (564-692): 5.97e-20: 97: 16.92		CMKMT_HUMAN (32-218): 1.04e-47: 160: 19.07
+	Hs
		504677 HSP7C_HUMAN (564-692): 5.97e-20: 97: 16.92		MET22_HUMAN (7-200): 7.21e-40: 142: 21.36
+	Hs
		714062 HS71L_HUMAN (564-691): 7.22e-19: 93.5: 22.48		MET22_HUMAN (7-200): 7.21e-40: 142: 21.36
+	Hs
		504646 HSP7C_HUMAN (564-692): 5.97e-20: 97: 16.92		ANM1_HUMAN (57-208): 1.75e-33: 125: 16.03
+	Hs
		504370 HSP7C_HUMAN (564-692): 5.97e-20: 97: 16.92		ETKMT_HUMAN (44-176): 3.41e-28: 108: 22.96