HitPredict

Interactor 1: HSP74 (P34932)
Heat shock 70 kDa protein 4 (HSP70RY) (Heat shock 70-related protein APG-2) (Heat shock protein family H member 2)
Gene: HSPA4

Interactor 2: CSN5 (Q92905)
COP9 signalosome complex subunit 5 (SGN5) (Signalosome subunit 5) (EC 3.4.-.-) (Jun activation domain-binding protein 1)
Gene: COPS5

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	21145461
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 840 Hs			1 334
+	Hs
		320891 HS74L_HUMAN (1-840): 0: 959: 63.21		CSN5_HUMAN (1-334): 6.64e-131: 378: 100.00
+	Hs
		1267726 HS105_HUMAN (1-840): 0: 938: 62.95		CSN5_HUMAN (1-334): 6.64e-131: 378: 100.00
+	Hs
		130766 HSP74_HUMAN (1-840): 0: 993: 100.00		PSDE_HUMAN (50-331): 1.67e-79: 246: 31.51
+	Hs
		130680 HS74L_HUMAN (1-840): 0: 959: 63.21		PSDE_HUMAN (50-331): 1.67e-79: 246: 31.51
+	Hs
		131024 HS105_HUMAN (1-840): 0: 938: 62.95		PSDE_HUMAN (50-331): 1.67e-79: 246: 31.51
+	Sc
		694940 HSP7F_YEAST (5-697): 5.7e-137: 424: 37.61		RPN11_YEAST (39-333): 9.57e-75: 234: 29.14
+	Sc
		695695 HSP7F_YEAST (5-697): 5.7e-137: 424: 37.61		RPN8_YEAST (53-326): 4.45e-57: 190: 16.61
+	Hs
		504512 HSP7C_HUMAN (564-692): 5.97e-20: 97: 16.92		CSN5_HUMAN (1-334): 6.64e-131: 378: 100.00
+	Hs
		714039 HS71L_HUMAN (564-691): 7.22e-19: 93.5: 22.48		CSN5_HUMAN (1-334): 6.64e-131: 378: 100.00
+	Hs
		564143 HSP76_HUMAN (587-690): 1.94e-16: 85.8: 22.86		CSN5_HUMAN (1-334): 6.64e-131: 378: 100.00
+	Hs
		130712 HSP7C_HUMAN (564-692): 5.97e-20: 97: 16.92		PSDE_HUMAN (50-331): 1.67e-79: 246: 31.51
+	Hs
		124744 HSP7C_HUMAN (564-692): 5.97e-20: 97: 16.92		EIF3F_HUMAN (44-328): 3.25e-64: 208: 14.48