HitPredict

Interactor 1: HSP74 (P34932)
Heat shock 70 kDa protein 4 (HSP70RY) (Heat shock 70-related protein APG-2) (Heat shock protein family H member 2)
Gene: HSPA4

Interactor 2: CHIP (Q9UNE7)
E3 ubiquitin-protein ligase CHIP (EC 2.3.2.27) (Antigen NY-CO-7) (CLL-associated antigen KW-8) (Carboxy terminus of Hsp70-interacting protein) (RING-type E3 ubiquitin transferase CHIP) (STIP1 homology and U box-containing protein 1)
Gene: STUB1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.99 1.00 0.996

The method score is based on:

Property Details
Experiments 27708256, 29274099, 30446660, 30911017, 33619536, 17545168, 35657686, 36027913, 17317785, 21454478, 20349136, 14532117, 21775628, 22824801, 20661446, 23271055, 23412384, 23410750, 26010904, 28754656 and 30 others

more...
Identification Methods affinity chromatography technology, pull down, x-ray crystallography, unspecified method, enzymatic study, two hybrid
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains ANAPC3~HSP70
Common GO terms GO:0005634 - nucleus
GO:0005739 - mitochondrion
GO:0005829 - cytosol
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 840
Hs

1 303
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Last updated: 15 Jul 2024