HitPredict

Interactor 1: HSP74 (P34932)
Heat shock 70 kDa protein 4 (HSP70RY) (Heat shock 70-related protein APG-2) (Heat shock protein family H member 2)
Gene: HSPA4

Interactor 2: HDAC5 (Q9UQL6)
Histone deacetylase 5 (HD5) (EC 3.5.1.98) (Antigen NY-CO-9)
Gene: HDAC5

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	21081666
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 840 Hs			1 1122
+	Mm
		1112337 Q3U2G2_MOUSE (1-840): 0: 970: 95.61		Q3UJF1_MOUSE (1-1122): 0: 717: 92.71
+	Mm
		1142530 HSP74_MOUSE (1-840): 0: 966: 95.25		HDAC5_MOUSE (1-1122): 0: 713: 92.17
+	Mm
		821831 HS74L_MOUSE (1-840): 0: 962: 61.91		HDAC4_MOUSE (1-1103): 0: 651: 53.34
+	Hs
		714217 HSP74_HUMAN (1-840): 0: 993: 100.00		HDAC1_HUMAN (673-1103): 1.54e-153: 468: 21.16
+	Hs
		714337 HSP74_HUMAN (1-840): 0: 993: 100.00		HDAC2_HUMAN (680-1113): 1.34e-153: 468: 21.68
+	Hs
		177212 HSP74_HUMAN (1-840): 0: 993: 100.00		HDAC3_HUMAN (679-1119): 5.97e-144: 441: 21.57
+	Hs
		714445 HSP74_HUMAN (1-840): 0: 993: 100.00		HDAC6_HUMAN (599-1061): 7.06e-106: 362: 31.97
+	Hs
		1267771 HS105_HUMAN (1-840): 0: 938: 62.95		HDAC6_HUMAN (599-1061): 7.06e-106: 362: 31.97
+	Sc
		692996 HSP7F_YEAST (5-697): 5.7e-137: 424: 37.61		RPD3_YEAST (665-1098): 4.72e-146: 446: 22.00
+	Hs
		503771 HSP7C_HUMAN (564-692): 5.97e-20: 97: 16.92		HDAC4_HUMAN (1-1101): 0: 653: 54.96
+	Hs
		504036 HSP7C_HUMAN (564-692): 5.97e-20: 97: 16.92		HDAC1_HUMAN (673-1103): 1.54e-153: 468: 21.16
+	Hs
		504501 HSP7C_HUMAN (564-692): 5.97e-20: 97: 16.92		HDAC2_HUMAN (680-1113): 1.34e-153: 468: 21.68
+	Hs
		564072 HSP76_HUMAN (587-690): 1.94e-16: 85.8: 22.86		HDAC1_HUMAN (673-1103): 1.54e-153: 468: 21.16
+	Hs
		177179 HSP7C_HUMAN (564-692): 5.97e-20: 97: 16.92		HDAC3_HUMAN (679-1119): 5.97e-144: 441: 21.57
+	Hs
		504526 HSP7C_HUMAN (564-692): 5.97e-20: 97: 16.92		HDA10_HUMAN (681-1067): 7.89e-138: 433: 34.36
+	Hs
		504893 HSP7C_HUMAN (564-692): 5.97e-20: 97: 16.92		HDAC6_HUMAN (599-1061): 7.06e-106: 362: 31.97
+	Hs
		714086 HS71L_HUMAN (564-691): 7.22e-19: 93.5: 22.48		HDAC6_HUMAN (599-1061): 7.06e-106: 362: 31.97
+	Hs
		564200 HSP76_HUMAN (587-690): 1.94e-16: 85.8: 22.86		HDAC6_HUMAN (599-1061): 7.06e-106: 362: 31.97
+	Hs
		1120593 Q53FC7_HUMAN (587-690): 3.01e-16: 85.1: 22.86		HDAC6_HUMAN (599-1061): 7.06e-106: 362: 31.97