HitPredict

Interactor 1: GRK5 (P34947)
G protein-coupled receptor kinase 5 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK5)
Gene: GRK5

Interactor 2: SYUA (P37840)
Alpha-synuclein (Non-A beta component of AD amyloid) (Non-A4 component of amyloid precursor) (NACP)
Gene: SNCA

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	10852916
Identification Methods	enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005543 - phospholipid binding GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0043066 - negative regulation of apoptotic process
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1 590 Hs			1 140
+	Hs
		742110 GRK6_HUMAN (1-558): 0: 525: 72.27		SYUA_HUMAN (1-140): 5.01e-57: 175: 100.00
+	Hs
		714539 GRK5_HUMAN (1-590): 0: 550: 100.00		SYUB_HUMAN (1-126): 2.84e-36: 122: 58.02
+	Hs
		282769 GRK5_HUMAN (1-590): 0: 550: 100.00		SYUG_HUMAN (1-100): 1.25e-28: 103: 66.00
+	Hs
		794388 GRK6_HUMAN (1-558): 0: 525: 72.27		SYUB_HUMAN (1-126): 2.84e-36: 122: 58.02
+	Hs
		742316 GRK1_HUMAN (3-537): 1.79e-154: 456: 47.41		SYUA_HUMAN (1-140): 5.01e-57: 175: 100.00
+	Hs
		282772 GRK6_HUMAN (1-558): 0: 525: 72.27		SYUG_HUMAN (1-100): 1.25e-28: 103: 66.00
+	Hs
		566312 KPCA_HUMAN (12-509): 5.54e-142: 428: 25.29		SYUA_HUMAN (1-140): 5.01e-57: 175: 100.00
+	Hs
		626629 ARBK1_HUMAN (2-556): 3.02e-141: 427: 34.74		SYUA_HUMAN (1-140): 5.01e-57: 175: 100.00
+	Hs
		681700 AKT1_HUMAN (68-517): 2.1e-141: 420: 29.19		SYUA_HUMAN (1-140): 5.01e-57: 175: 100.00
+	Hs
		742230 KPCE_HUMAN (85-503): 2.08e-136: 416: 30.30		SYUA_HUMAN (1-140): 5.01e-57: 175: 100.00
+	Hs
		1079321 GRK1_HUMAN (3-537): 1.79e-154: 456: 47.41		SYUB_HUMAN (1-126): 2.84e-36: 122: 58.02
+	Hs
		282779 GRK1_HUMAN (3-537): 1.79e-154: 456: 47.41		SYUG_HUMAN (1-100): 1.25e-28: 103: 66.00
+	Hs
		681868 AKT1_HUMAN (68-517): 2.1e-141: 420: 29.19		SYUB_HUMAN (1-126): 2.84e-36: 122: 58.02