HitPredict

Interactor 1: MMP12 (P34960)
Macrophage metalloelastase (MME) (EC 3.4.24.65) (Matrix metalloproteinase-12) (MMP-12)
Gene: MMP12

Interactor 2: CXCL3 (Q6W5C0)
C-X-C motif chemokine 3 (Dendritic cell inflammatory protein 1)
Gene: CXCL3

Species: Mus musculus

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	18660381
Identification Methods	protease assay
Interaction Type	protein cleavage

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005615 - extracellular space
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 473 Mm			1 100
+	Mm
		500671 MMP12_MOUSE (1-473): 0: 646: 100.00		CXCL2_MOUSE (1-100): 6.5e-34: 114: 82.00
+	Hs
		587770 MMP12_HUMAN (12-473): 0: 646: 61.57		CXCL2_HUMAN (22-100): 2.65e-28: 100: 58.23
+	Mm
		714630 MMP12_MOUSE (1-473): 0: 646: 100.00		CXCL5_MOUSE (4-98): 2.63e-27: 98.6: 43.43
+	Hs
		364043 MMP12_HUMAN (12-473): 0: 646: 61.57		CXCL7_HUMAN (30-100): 4.19e-27: 97.8: 46.48
+	Hs
		764724 MMP12_HUMAN (12-473): 0: 646: 61.57		CXCL5_HUMAN (20-97): 2.44e-27: 97.8: 42.31
+	Hs
		448989 MMP12_HUMAN (12-473): 0: 646: 61.57		GROA_HUMAN (30-100): 9.97e-27: 96.3: 59.16
+	Mm
		522396 MMP12_MOUSE (1-473): 0: 646: 100.00		GROA_MOUSE (26-96): 5.95e-27: 96.3: 60.56
+	Hs
		587787 MMP12_HUMAN (12-473): 0: 646: 61.57		CXCL3_HUMAN (30-100): 2.5e-26: 95.1: 57.75
+	Hs
		764727 MMP12_HUMAN (12-473): 0: 646: 61.57		CXCL6_HUMAN (23-97): 4.31e-25: 92.4: 46.67
+	Hs
		486188 MMP12_HUMAN (12-473): 0: 646: 61.57		IL8_HUMAN (20-100): 6.69e-24: 88.9: 38.82
+	Hs
		486190 MMP13_HUMAN (15-473): 0: 630: 43.83		IL8_HUMAN (20-100): 6.69e-24: 88.9: 38.82
+	Hs
		372731 MMP1_HUMAN (32-473): 0: 612: 45.60		CXCL2_HUMAN (22-100): 2.65e-28: 100: 58.23
+	Hs
		364034 MMP1_HUMAN (32-473): 0: 612: 45.60		CXCL7_HUMAN (30-100): 4.19e-27: 97.8: 46.48
+	Hs
		372733 MMP1_HUMAN (32-473): 0: 612: 45.60		CXCL5_HUMAN (20-97): 2.44e-27: 97.8: 42.31
+	Hs
		372737 MMP1_HUMAN (32-473): 0: 612: 45.60		CXCL6_HUMAN (23-97): 4.31e-25: 92.4: 46.67
+	Hs
		612139 MMP8_HUMAN (23-473): 0: 605: 43.74		CXCL5_HUMAN (20-97): 2.44e-27: 97.8: 42.31
+	Hs
		372724 MMP1_HUMAN (32-473): 0: 612: 45.60		IL8_HUMAN (20-100): 6.69e-24: 88.9: 38.82
+	Hs
		486182 MMP8_HUMAN (23-473): 0: 605: 43.74		IL8_HUMAN (20-100): 6.69e-24: 88.9: 38.82
+	Hs
		364037 MMP9_HUMAN (31-210): 7.08e-68: 231: 43.33		CXCL7_HUMAN (30-100): 4.19e-27: 97.8: 46.48
+	Hs
		486175 MMP9_HUMAN (31-210): 7.08e-68: 231: 43.33		IL8_HUMAN (20-100): 6.69e-24: 88.9: 38.82