HitPredict

Interactor 1: CRFR1 (P34998)
Corticotropin-releasing factor receptor 1 (CRF-R-1) (CRF-R1) (CRFR-1) (Corticotropin-releasing hormone receptor 1) (CRH-R-1) (CRH-R1)
Gene: CRHR1

Interactor 2: NHRF3 (Q5T2W1)
Na(+)/H(+) exchange regulatory cofactor NHE-RF3 (NHERF-3) (CFTR-associated protein of 70 kDa) (Na(+)/H(+) exchanger regulatory factor 3) (Na/Pi cotransporter C-terminal-associated protein 1) (NaPi-Cap1) (PDZ domain-containing protein 1) (Sodium-hydrogen exchanger regulatory factor 3)
Gene: PDZK1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	23576434
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 415 Hs			1 519
+	Mm
		722927 CRFR1_MOUSE (1-415): 1.03e-129: 381: 97.59		DLG4_MOUSE (3-344): 3.77e-36: 144: 16.96
+	Hs
		714731 CRFR1_HUMAN (1-415): 8.88e-129: 379: 100.00		DLG4_HUMAN (3-344): 2.27e-36: 145: 17.22
+	Mm
		1143372 AGRL3_MOUSE (1-413): 4.15e-117: 375: 19.18		DLG4_MOUSE (3-344): 3.77e-36: 144: 16.96
+	Mm
		722926 CRFR1_MOUSE (1-415): 1.03e-129: 381: 97.59		DLG3_MOUSE (3-359): 7.92e-32: 132: 17.27
+	Mm
		1143371 AGRL1_MOUSE (6-413): 6.78e-113: 362: 18.20		DLG4_MOUSE (3-344): 3.77e-36: 144: 16.96
+	Hs
		714732 CRFR1_HUMAN (1-415): 8.88e-129: 379: 100.00		PTN13_HUMAN (72-497): 1.88e-29: 125: 12.84
+	Hs
		714738 CRFR1_HUMAN (1-415): 8.88e-129: 379: 100.00		MAGI1_HUMAN (183-460): 1.21e-20: 98.3: 19.89
+	Hs
		714734 CRFR1_HUMAN (1-415): 8.88e-129: 379: 100.00		SCRIB_HUMAN (125-505): 6.83e-20: 96: 10.97
+	Hs
		280026 CRFR1_HUMAN (1-415): 8.88e-129: 379: 100.00		MPDZ_HUMAN (10-473): 3.69e-17: 87.5: 9.68
+	Hs
		714733 CRFR1_HUMAN (1-415): 8.88e-129: 379: 100.00		DLG1_HUMAN (289-461): 1.6e-16: 85.1: 18.52
+	Hs
		714737 CRFR1_HUMAN (1-415): 8.88e-129: 379: 100.00		MAGI2_HUMAN (76-502): 3.32e-13: 74.8: 12.13
+	Hs
		714736 CRFR1_HUMAN (1-415): 8.88e-129: 379: 100.00		MAGI3_HUMAN (174-503): 8.59e-11: 67.1: 13.01
+	Mm
		1143383 AGRB3_MOUSE (4-392): 9.99e-81: 272: 19.48		DLG4_MOUSE (3-344): 3.77e-36: 144: 16.96
+	Mm
		1112552 AGRB1_MOUSE (3-377): 2.02e-80: 271: 19.95		DLG4_MOUSE (3-344): 3.77e-36: 144: 16.96
+	Hs
		146752 AGRB1_HUMAN (3-377): 4.14e-79: 268: 19.69		DLG4_HUMAN (3-344): 2.27e-36: 145: 17.22
+	Hs
		153910 PTH1R_HUMAN (41-411): 1.43e-98: 307: 29.66		NHRF1_HUMAN (5-134): 6.99e-24: 104: 31.54
+	Hs
		976333 PTH1R_HUMAN (41-411): 1.43e-98: 307: 29.66		NHRF2_HUMAN (5-146): 7.72e-20: 92.8: 28.17
+	Hs
		819563 GIPR_HUMAN (17-413): 1.2e-93: 291: 26.49		LNX1_HUMAN (4-213): 1.57e-20: 97.1: 16.74
+	Hs
		146753 AGRB1_HUMAN (3-377): 4.14e-79: 268: 19.69		DLG1_HUMAN (289-461): 1.6e-16: 85.1: 18.52
+	Hs
		146758 AGRB1_HUMAN (3-377): 4.14e-79: 268: 19.69		MAGI3_HUMAN (174-503): 8.59e-11: 67.1: 13.01