HitPredict

Interactor 1: PROF2 (P35080)
Profilin-2 (Profilin II)
Gene: PFN2

Interactor 2: VASP (P50552)
Vasodilator-stimulated phosphoprotein (VASP)
Gene: VASP

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.83	0.60	0.708

Property	Details
Experiments	10882740, 28514442, 7737110, 33961781
Identification Methods	two hybrid, affinity chromatography technology, pull down, biochemical, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003779 - actin binding GO:0030036 - actin cytoskeleton organization GO:0030838 - positive regulation of actin filament polymerization GO:0070062 - extracellular exosome
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 140 Hs			1 380
+	Mm
		936836 PROF2_MOUSE (1-140): 3.3e-76: 224: 99.29		VASP_MOUSE (1-380): 3.09e-96: 293: 87.63
+	Hs
		430098 PROF1_HUMAN (1-140): 4.25e-74: 219: 61.43		VASP_HUMAN (1-380): 1.43e-91: 281: 100.00
+	Hs
		715013 PROF2_HUMAN (1-140): 2.83e-76: 224: 100.00		EVL_HUMAN (1-375): 2.06e-60: 202: 43.68
+	Hs
		430372 PROF1_HUMAN (1-140): 4.25e-74: 219: 61.43		EVL_HUMAN (1-375): 2.06e-60: 202: 43.68
+	Hs
		714977 PROF2_HUMAN (1-140): 2.83e-76: 224: 100.00		ENAH_HUMAN (109-379): 3.91e-23: 102: 30.06
+	Hs
		430264 PROF1_HUMAN (1-140): 4.25e-74: 219: 61.43		ENAH_HUMAN (109-379): 3.91e-23: 102: 30.06
+	Mm
		975407 PROF2_MOUSE (1-140): 3.3e-76: 224: 99.29		ENAH_MOUSE (109-379): 3.12e-16: 82.4: 28.17
+	Mm
		923919 PROF1_MOUSE (1-140): 1.25e-73: 217: 62.86		ENAH_MOUSE (109-379): 3.12e-16: 82.4: 28.17
+	Mm
		1337493 PROF2_MOUSE (1-140): 3.3e-76: 224: 99.29		PCLO_MOUSE (95-300): 3.82e-09: 60.8: 13.59
+	Mm
		923936 PROF1_MOUSE (1-140): 1.25e-73: 217: 62.86		PCLO_MOUSE (95-300): 3.82e-09: 60.8: 13.59