HitPredict

Interactor 1: PROF2 (P35080)
Profilin-2 (Profilin II)
Gene: PFN2

Interactor 2: ACTA (P62736)
Actin, aortic smooth muscle (EC 3.6.4.-) (Alpha-actin-2) (Cell growth-inhibiting gene 46 protein) [Cleaved into: Actin, aortic smooth muscle, intermediate form]
Gene: ACTA2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	1.00	0.811

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Actin~Profilin
Common GO terms	GO:0005737 - cytoplasm GO:0070062 - extracellular exosome
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 140 Hs			1 377
+	Hs
		714971 PROF2_HUMAN (1-140): 2.83e-76: 224: 100.00		ACTBL_HUMAN (4-377): 0: 712: 87.97
+	Hs
		891642 PROF3_HUMAN (1-139): 1.11e-64: 195: 41.01		ACTBL_HUMAN (4-377): 0: 712: 87.97
+	Hs
		714946 PROF2_HUMAN (1-140): 2.83e-76: 224: 100.00		ACTB_HUMAN (4-377): 0: 598: 94.12
+	Hs
		714953 PROF2_HUMAN (1-140): 2.83e-76: 224: 100.00		ACTG_HUMAN (4-377): 0: 598: 94.39
+	Hs
		714954 PROF2_HUMAN (1-140): 2.83e-76: 224: 100.00		ACTC_HUMAN (1-377): 0: 598: 98.41
+	Mm
		892215 PROF2_MOUSE (1-140): 3.3e-76: 224: 99.29		ACTB_MOUSE (4-377): 0: 598: 94.12
+	Bt
		361199 PROF1_BOVIN (1-140): 1.62e-74: 219: 62.14		ACTB_BOVIN (4-377): 0: 598: 94.12
+	Bt
		361200 PROF1_BOVIN (1-140): 1.62e-74: 219: 62.14		ACTS_BOVIN (1-377): 0: 598: 97.88
+	Hs
		430115 PROF1_HUMAN (1-140): 4.25e-74: 219: 61.43		ACTB_HUMAN (4-377): 0: 598: 94.12
+	Hs
		430128 PROF1_HUMAN (1-140): 4.25e-74: 219: 61.43		ACTG_HUMAN (4-377): 0: 598: 94.39
+	Hs
		430130 PROF1_HUMAN (1-140): 4.25e-74: 219: 61.43		ACTC_HUMAN (1-377): 0: 598: 98.41
+	Hs
		430125 PROF1_HUMAN (1-140): 4.25e-74: 219: 61.43		ACTA_HUMAN (1-377): 0: 596: 100.00
+	Mm
		892155 PROF1_MOUSE (1-140): 1.25e-73: 217: 62.86		ACTB_MOUSE (4-377): 0: 598: 94.12
+	Hs
		891639 PROF3_HUMAN (1-139): 1.11e-64: 195: 41.01		ACTB_HUMAN (4-377): 0: 598: 94.12
+	Hs
		891641 PROF3_HUMAN (1-139): 1.11e-64: 195: 41.01		ACTC_HUMAN (1-377): 0: 598: 98.41
+	Hs
		891640 PROF3_HUMAN (1-139): 1.11e-64: 195: 41.01		ACTA_HUMAN (1-377): 0: 596: 100.00