HitPredict

Interactor 1: UBC2 (P35129)
Ubiquitin-conjugating enzyme E2 2 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme 2) (Lethal protein 70) (Ubiquitin carrier protein 2) (Ubiquitin-protein ligase 2)
Gene: let-70

Interactor 2: APC11 (Q20052)
Anaphase-promoting complex subunit 11 (APC11)
Gene: apc-11

Species: Caenorhabditis elegans

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	1.00	0.767

Property	Details
Experiments	15466891, 15530417
Identification Methods	enzymatic study, two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	UQ_con~zf-ANAPC11
Common GO terms	GO:0004842 - ubiquitin-protein transferase activity GO:0005634 - nucleus GO:0006511 - ubiquitin-dependent protein catabolic process GO:0016567 - protein ubiquitination
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 147 Ce			1 135
+	Hs
		921482 UB2D4_HUMAN (1-147): 3.06e-83: 242: 92.52		RBX1_HUMAN (31-135): 1.55e-40: 132: 27.27
+	Hs
		849303 UB2D1_HUMAN (1-147): 2.25e-82: 240: 89.12		RBX1_HUMAN (31-135): 1.55e-40: 132: 27.27
+	Mm
		895979 UB2D1_MOUSE (1-147): 2.25e-82: 240: 89.12		RBX1_MOUSE (31-135): 1.55e-40: 132: 27.27
+	Hs
		919703 UB2D2_HUMAN (1-147): 5.79e-82: 239: 93.88		RBX1_HUMAN (31-135): 1.55e-40: 132: 27.27
+	Mm
		919923 UB2D2_MOUSE (1-147): 5.79e-82: 239: 93.88		RBX1_MOUSE (31-135): 1.55e-40: 132: 27.27
+	Hs
		895771 UB2D3_HUMAN (1-147): 8.04e-81: 236: 92.52		RBX1_HUMAN (31-135): 1.55e-40: 132: 27.27
+	Mm
		895973 UB2D3_MOUSE (1-147): 8.04e-81: 236: 92.52		RBX1_MOUSE (31-135): 1.55e-40: 132: 27.27
+	Sc
		549843 UBC4_YEAST (3-147): 3.66e-79: 232: 79.31		RBX1_YEAST (6-135): 3.88e-36: 122: 27.41
+	Sc
		549867 UBC5_YEAST (3-147): 1.02e-78: 231: 80.00		RBX1_YEAST (6-135): 3.88e-36: 122: 27.41
+	Ce
		715111 UBC2_CAEEL (1-147): 4.45e-82: 239: 100.00		RBX1_CAEEL (46-135): 4.6e-33: 113: 29.47
+	Hs
		849463 UB2D1_HUMAN (1-147): 2.25e-82: 240: 89.12		APC11_HUMAN (49-135): 1.56e-32: 111: 48.28
+	Hs
		919882 UB2D2_HUMAN (1-147): 5.79e-82: 239: 93.88		APC11_HUMAN (49-135): 1.56e-32: 111: 48.28
+	Sp
		804461 UBC4_SCHPO (1-147): 3.78e-80: 234: 85.71		APC11_SCHPO (49-135): 2.29e-33: 114: 40.23
+	Hs
		895932 UB2D3_HUMAN (1-147): 8.04e-81: 236: 92.52		APC11_HUMAN (49-135): 1.56e-32: 111: 48.28
+	Sc
		549847 UBC4_YEAST (3-147): 3.66e-79: 232: 79.31		APC11_YEAST (49-135): 1e-32: 114: 36.54
+	Sc
		549868 UBC5_YEAST (3-147): 1.02e-78: 231: 80.00		APC11_YEAST (49-135): 1e-32: 114: 36.54
+	Hs
		1354003 UB2D4_HUMAN (1-147): 3.06e-83: 242: 92.52		RBX2_HUMAN (49-135): 6.92e-26: 95.6: 33.71
+	Hs
		849472 UB2D1_HUMAN (1-147): 2.25e-82: 240: 89.12		RBX2_HUMAN (49-135): 6.92e-26: 95.6: 33.71
+	Hs
		919890 UB2D2_HUMAN (1-147): 5.79e-82: 239: 93.88		RBX2_HUMAN (49-135): 6.92e-26: 95.6: 33.71
+	Hs
		895936 UB2D3_HUMAN (1-147): 8.04e-81: 236: 92.52		RBX2_HUMAN (49-135): 6.92e-26: 95.6: 33.71