HitPredict

Interactor 1: CTNA1 (P35221)
Catenin alpha-1 (Alpha E-catenin) (Cadherin-associated protein) (Renal carcinoma antigen NY-REN-13)
Gene: CTNNA1

Interactor 2: ZO1 (Q07157)
Tight junction protein ZO-1 (Tight junction protein 1) (Zona occludens protein 1) (Zonula occludens protein 1)
Gene: TJP1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	34079125, 37381005
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0005912 - adherens junction GO:0030054 - cell junction GO:0045296 - cadherin binding and 1 others more... GO:0098609 - cell-cell adhesion
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 906 Hs			1 1748
+	Mm
		640686 CTNA1_MOUSE (1-906): 0: 1074: 99.45		ZO1_MOUSE (1-1748): 0: 874: 90.79
+	Hs
		716666 CTNA1_HUMAN (1-906): 0: 1080: 100.00		PTN13_HUMAN (20-492): 4.02e-23: 110: 16.63
+	Hs
		716736 CTNA1_HUMAN (1-906): 0: 1080: 100.00		DLG5_HUMAN (262-508): 3.83e-17: 90.3: 21.43
+	Hs
		716668 CTNA1_HUMAN (1-906): 0: 1080: 100.00		DLG1_HUMAN (263-512): 3.61e-17: 90: 16.54
+	Hs
		575732 VINC_HUMAN (22-607): 1.07e-66: 244: 17.56		ZO1_HUMAN (1-1748): 0: 925: 100.00
+	Hs
		716796 CTNA1_HUMAN (1-906): 0: 1080: 100.00		ZO2_HUMAN (391-610): 1e-09: 65.7: 17.98
+	Mm
		761856 VINC_MOUSE (22-592): 5.66e-66: 242: 17.83		ZO1_MOUSE (1-1748): 0: 874: 90.79
+	Hs
		159284 CTNL1_HUMAN (147-847): 1.84e-63: 230: 14.83		CSKP_HUMAN (217-806): 6.5e-86: 305: 14.66
+	Hs
		280017 VINC_HUMAN (22-607): 1.07e-66: 244: 17.56		MPDZ_HUMAN (31-489): 8.85e-18: 92.6: 13.61