HitPredict

Interactor 1: CTNB1 (P35222)
Catenin beta-1 (Beta-catenin)
Gene: CTNNB1

Interactor 2: TCF7 (P36402)
Transcription factor 7 (TCF-7) (T-cell-specific transcription factor 1) (T-cell factor 1) (TCF-1)
Gene: TCF7

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.86	1.00	0.931

Property	Details
Experiments	27684187, 37303493, 17510365, 19358846, unassigned650, 16442529
Identification Methods	affinity chromatography technology, tandem affinity purification, pull down, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation
Interaction Type	physical association, association, direct interaction

Property	Details
Interacting Pfam domains	Arm~CTNNB1_binding, Arm~HMG_box
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0060070 - canonical Wnt signaling pathway GO:1990907 - beta-catenin-TCF complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 781 Hs			1 384
+	Hs
		717411 CTNB1_HUMAN (1-781): 0: 626: 100.00		LEF1_HUMAN (1-362): 7.68e-46: 163: 43.60
+	Mm
		653458 CTNB1_MOUSE (1-781): 0: 624: 99.87		LEF1_MOUSE (1-362): 2.43e-42: 154: 42.86
+	Mm
		970158 CTNB1_MOUSE (1-781): 0: 624: 99.87		TF7L2_MOUSE (22-359): 6.56e-41: 151: 40.20
+	Xl
		640752 CTNB1_XENLA (1-781): 0: 615: 97.44		T7L1A_XENLA (1-384): 3.21e-42: 157: 36.77
+	Hs
		717362 CTNB1_HUMAN (1-781): 0: 626: 100.00		TF7L1_HUMAN (15-384): 1.67e-35: 139: 36.51
+	Mm
		970176 CTNB1_MOUSE (1-781): 0: 624: 99.87		TF7L1_MOUSE (15-384): 2.97e-36: 140: 36.59
+	Hs
		717368 CTNB1_HUMAN (1-781): 0: 626: 100.00		TF7L2_HUMAN (22-359): 5.5e-33: 132: 37.32
+	Hs
		716868 CTNB1_HUMAN (1-781): 0: 626: 100.00		SOX2_HUMAN (237-352): 1.31e-34: 131: 25.86
+	Hs
		717348 CTNB1_HUMAN (1-781): 0: 626: 100.00		SOX17_HUMAN (201-381): 7.04e-30: 120: 19.34
+	Mm
		970139 CTNB1_MOUSE (1-781): 0: 624: 99.87		SOX17_MOUSE (201-383): 8.08e-30: 120: 19.13
+	Dr
		1225024 Q8JID2_DANRE (1-781): 0: 570: 94.75		Q9W7C0_DANRE (1-361): 3.61e-48: 169: 44.83
+	Hs
		716823 CTNB1_HUMAN (1-781): 0: 626: 100.00		SOX6_HUMAN (261-352): 1.35e-23: 104: 32.61
+	Mm
		776233 CTNB1_MOUSE (1-781): 0: 624: 99.87		SOX6_MOUSE (261-352): 6.91e-23: 102: 32.61
+	Mm
		818698 CTNB1_MOUSE (1-781): 0: 624: 99.87		SOX2_MOUSE (238-352): 1.09e-15: 79.2: 25.86
+	Dm
		578629 ARM_DROME (1-780): 9.15e-160: 486: 64.49		PANG1_DROME (1-367): 1.27e-54: 193: 34.85
+	Hs
		542475 PLAK_HUMAN (8-752): 2.69e-158: 479: 67.42		LEF1_HUMAN (1-362): 7.68e-46: 163: 43.60
+	Hs
		542455 PLAK_HUMAN (8-752): 2.69e-158: 479: 67.42		TF7L2_HUMAN (22-359): 5.5e-33: 132: 37.32
+	Dm
		578667 ARM_DROME (1-780): 9.15e-160: 486: 64.49		PANG2_DROME (246-367): 1.38e-29: 122: 63.93
+	Hs
		542421 PLAK_HUMAN (8-752): 2.69e-158: 479: 67.42		CIC_HUMAN (92-381): 8.19e-29: 120: 18.62
+	Ce
		1014329 BAR1_CAEEL (129-740): 4.72e-102: 334: 24.15		POP1_CAEEL (14-366): 6.48e-34: 132: 22.25