HitPredict

Interactor 1: CTNB1 (P35222)
Catenin beta-1 (Beta-catenin)
Gene: CTNNB1

Interactor 2: NOTC1 (P46531)
Neurogenic locus notch homolog protein 1 (Notch 1) (hN1) (Translocation-associated notch protein TAN-1) [Cleaved into: Notch 1 extracellular truncation (NEXT); Notch 1 intracellular domain (NICD)]
Gene: NOTCH1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.64 0.60 0.624

The method score is based on:

Property Details
Experiments 19000719, 33189893
Identification Methods affinity chromatography technology, pull down, anti bait coimmunoprecipitation
Interaction Type physical association, direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0001701 - in utero embryonic development
GO:0001837 - epithelial to mesenchymal transition
GO:0002052 - positive regulation of neuroblast proliferation
GO:0003151 - outflow tract morphogenesis
and 21 others

more...
Homologous interactions 8

Homologous interactions

Color coding for hit scores

1 781
Hs

1 2555
+ Hs
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+ Mm
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+ Dm

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024