HitPredict

Interactor 1: CTNB1 (P35222)
Catenin beta-1 (Beta-catenin)
Gene: CTNNB1

Interactor 2: CAD12 (P55289)
Cadherin-12 (Brain cadherin) (BR-cadherin) (Neural type cadherin 2) (N-cadherin 2)
Gene: CDH12

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Arm~CADH_Y-type_LIR
Common GO terms	GO:0005886 - plasma membrane GO:0005912 - adherens junction GO:0016342 - catenin complex GO:0045296 - cadherin binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 781 Hs			1 794
+	Hs
		717472 CTNB1_HUMAN (1-781): 0: 626: 100.00		CAD10_HUMAN (1-791): 0: 802: 60.50
+	Hs
		716915 CTNB1_HUMAN (1-781): 0: 626: 100.00		CADH8_HUMAN (1-791): 0: 781: 54.92
+	Mm
		454955 CTNB1_MOUSE (1-781): 0: 624: 99.87		CADH1_MOUSE (30-788): 0: 615: 32.91
+	Hs
		717082 CTNB1_HUMAN (1-781): 0: 626: 100.00		DSC3_HUMAN (24-668): 1.63e-172: 521: 27.64
+	Hs
		717065 CTNB1_HUMAN (1-781): 0: 626: 100.00		CAD18_HUMAN (1-479): 3.1e-97: 321: 24.46
+	Hs
		716914 CTNB1_HUMAN (1-781): 0: 626: 100.00		CADH6_HUMAN (1-479): 4.46e-96: 318: 22.77
+	Hs
		702745 CTNB1_HUMAN (1-781): 0: 626: 100.00		CADH5_HUMAN (2-513): 2.14e-95: 316: 24.02
+	Hs
		716916 CTNB1_HUMAN (1-781): 0: 626: 100.00		CAD11_HUMAN (1-483): 3.75e-95: 316: 22.87
+	Hs
		717194 CTNB1_HUMAN (1-781): 0: 626: 100.00		CAD24_HUMAN (1-479): 2.51e-88: 298: 20.34
+	Hs
		716913 CTNB1_HUMAN (1-781): 0: 626: 100.00		CADH4_HUMAN (2-485): 2.88e-75: 264: 21.51
+	Gg
		193807 O42486_CHICK (1-781): 0: 633: 99.36		CADH2_CHICK (1-483): 2.72e-71: 253: 22.46
+	Hs
		717423 CTNB1_HUMAN (1-781): 0: 626: 100.00		CADH7_HUMAN (5-379): 2.78e-72: 253: 21.21
+	Rn
		1376711 CTNB1_RAT (1-781): 0: 625: 99.74		CADH2_RAT (1-479): 2.27e-71: 253: 22.81
+	Hs
		717422 CTNB1_HUMAN (1-781): 0: 626: 100.00		CADH9_HUMAN (2-380): 4.78e-62: 225: 18.20
+	Hs
		606301 CTNB1_HUMAN (1-781): 0: 626: 100.00		CADH3_HUMAN (5-412): 1.67e-59: 218: 23.67
+	Cl
		80821 CTNB1_CANLF (1-781): 0: 627: 99.87		CADH1_CANLF (1-481): 9.01e-53: 199: 21.12
+	Mm
		544708 CTNB1_MOUSE (1-781): 0: 624: 99.87		CADH2_MOUSE (2-302): 3.61e-38: 155: 20.25
+	Hs
		580207 CTNB1_HUMAN (1-781): 0: 626: 100.00		CADH2_HUMAN (269-736): 3.74e-37: 151: 16.60
+	Hs
		521758 CTNB1_HUMAN (1-781): 0: 626: 100.00		CADH1_HUMAN (2-377): 3.41e-35: 145: 19.70
+	Hs
		716918 CTNB1_HUMAN (1-781): 0: 626: 100.00		CAD15_HUMAN (5-257): 1.22e-11: 70.3: 13.50