HitPredict - High confidence protein-protein interactions

Interactor 1: CTNB1 (P35222)
Catenin beta-1 (Beta-catenin)
Gene: CTNNB1

Interactor 2: SMAD3 (P84022)
Mothers against decapentaplegic homolog 3 (MAD homolog 3) (Mad3) (Mothers against DPP homolog 3) (hMAD-3) (JV15-2) (SMAD family member 3) (SMAD 3) (Smad3) (hSMAD3)
Gene: SMAD3

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.82	0.60	0.702

Property	Details
Experiments	27684187, 12000714, 20571128, 21965288, 22241478
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0001222 - transcription corepressor binding GO:0001701 - in utero embryonic development GO:0005634 - nucleus GO:0005654 - nucleoplasm and 18 others more... GO:0005667 - transcription regulator complex GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0008285 - negative regulation of cell population proliferation GO:0010628 - positive regulation of gene expression GO:0010629 - negative regulation of gene expression GO:0010718 - positive regulation of epithelial to mesenchymal transition GO:0016922 - nuclear receptor binding GO:0019901 - protein kinase binding GO:0031625 - ubiquitin protein ligase binding GO:0043066 - negative regulation of apoptotic process GO:0045893 - positive regulation of DNA-templated transcription GO:0045944 - positive regulation of transcription by RNA polymerase II GO:0048617 - embryonic foregut morphogenesis GO:0061629 - RNA polymerase II-specific DNA-binding transcription factor binding GO:0070411 - I-SMAD binding GO:0140297 - DNA-binding transcription factor binding
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1	781
Hs

1	425

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Last updated: 15 Jul 2024