HitPredict

Interactor 1: CTNB1 (P35222)
Catenin beta-1 (Beta-catenin)
Gene: CTNNB1

Interactor 2: NTRK3 (Q16288)
NT-3 growth factor receptor (EC 2.7.10.1) (GP145-TrkC) (Trk-C) (Neurotrophic tyrosine kinase receptor type 3) (TrkC tyrosine kinase)
Gene: NTRK3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	35384245
Identification Methods	affinity chromatography technology, proximity labelling technology
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0008284 - positive regulation of cell population proliferation GO:0010628 - positive regulation of gene expression
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 781 Hs			1 839
+	Hs
		542340 PLAK_HUMAN (8-752): 2.69e-158: 479: 67.42		NTRK3_HUMAN (1-839): 0: 671: 100.00
+	Hs
		384375 CTNB1_HUMAN (1-781): 0: 626: 100.00		NTRK1_HUMAN (16-839): 8.14e-173: 520: 46.75
+	Hs
		507882 CTNB1_HUMAN (1-781): 0: 626: 100.00		FGFR1_HUMAN (162-838): 5.94e-163: 496: 23.43
+	Hs
		384204 PLAK_HUMAN (8-752): 2.69e-158: 479: 67.42		NTRK1_HUMAN (16-839): 8.14e-173: 520: 46.75
+	Hs
		434143 CTNB1_HUMAN (1-781): 0: 626: 100.00		RET_HUMAN (282-837): 1.5e-108: 360: 25.76
+	Hs
		507826 PLAK_HUMAN (8-752): 2.69e-158: 479: 67.42		FGFR1_HUMAN (162-838): 5.94e-163: 496: 23.43
+	Hs
		134907 IMA3_HUMAN (198-681): 7.05e-69: 237: 14.34		NTRK3_HUMAN (1-839): 0: 671: 100.00
+	Hs
		717128 CTNB1_HUMAN (1-781): 0: 626: 100.00		DDR2_HUMAN (527-824): 2.05e-70: 250: 43.30
+	Hs
		435557 CTNB1_HUMAN (1-781): 0: 626: 100.00		IGF1R_HUMAN (513-820): 3.56e-64: 236: 39.16
+	Rn
		544931 CTNB1_RAT (1-781): 0: 625: 99.74		INSR_RAT (513-824): 3.31e-62: 230: 38.80
+	Hs
		119752 ARVC_HUMAN (202-771): 5.66e-94: 316: 18.66		NTRK1_HUMAN (16-839): 8.14e-173: 520: 46.75
+	Hs
		238624 IMA7_HUMAN (200-683): 8.41e-73: 249: 16.97		NTRK1_HUMAN (16-839): 8.14e-173: 520: 46.75
+	Hs
		131365 IMA4_HUMAN (220-681): 6.79e-68: 235: 15.25		NTRK1_HUMAN (16-839): 8.14e-173: 520: 46.75
+	Hs
		384529 IMA1_HUMAN (237-675): 3.54e-66: 231: 18.54		NTRK1_HUMAN (16-839): 8.14e-173: 520: 46.75
+	Hs
		384530 IMA5_HUMAN (240-678): 2.52e-65: 228: 16.44		NTRK1_HUMAN (16-839): 8.14e-173: 520: 46.75
+	Hs
		542283 PLAK_HUMAN (8-752): 2.69e-158: 479: 67.42		ROR1_HUMAN (509-821): 2.63e-67: 243: 40.50
+	Hs
		435524 PLAK_HUMAN (8-752): 2.69e-158: 479: 67.42		IGF1R_HUMAN (513-820): 3.56e-64: 236: 39.16
+	Mm
		546270 PLAK_MOUSE (8-752): 6.82e-156: 473: 66.62		INSR_MOUSE (513-824): 2.11e-62: 231: 38.80
+	Hs
		717051 CTNB1_HUMAN (1-781): 0: 626: 100.00		PTK7_HUMAN (215-380): 9.02e-12: 71.3: 17.34