HitPredict

Interactor 1: CTNB1 (P35222)
Catenin beta-1 (Beta-catenin)
Gene: CTNNB1

Interactor 2: TF7L1 (Q9HCS4)
Transcription factor 7-like 1 (HMG box transcription factor 3) (TCF-3)
Gene: TCF7L1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.63	1.00	0.797

Property	Details
Experiments	15327769, 11136974, 29540185
Identification Methods	unspecified method, x-ray crystallography, coimmunoprecipitation
Interaction Type	direct interaction, association

Property	Details
Interacting Pfam domains	Arm~CTNNB1_binding, Arm~HMG_box
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0060070 - canonical Wnt signaling pathway GO:1990907 - beta-catenin-TCF complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 781 Hs			1 588
+	Mm
		970176 CTNB1_MOUSE (1-781): 0: 624: 99.87		TF7L1_MOUSE (30-588): 8.09e-76: 253: 96.42
+	Xl
		640752 CTNB1_XENLA (1-781): 0: 615: 97.44		T7L1A_XENLA (26-587): 6.87e-67: 229: 73.67
+	Hs
		717368 CTNB1_HUMAN (1-781): 0: 626: 100.00		TF7L2_HUMAN (37-586): 6.17e-51: 187: 50.58
+	Mm
		970158 CTNB1_MOUSE (1-781): 0: 624: 99.87		TF7L2_MOUSE (37-440): 3.88e-46: 170: 62.29
+	Hs
		716826 CTNB1_HUMAN (1-781): 0: 626: 100.00		TCF7_HUMAN (35-442): 2.13e-42: 158: 37.65
+	Mm
		653458 CTNB1_MOUSE (1-781): 0: 624: 99.87		LEF1_MOUSE (31-444): 6.41e-37: 143: 48.33
+	Hs
		717411 CTNB1_HUMAN (1-781): 0: 626: 100.00		LEF1_HUMAN (31-444): 3.38e-36: 141: 47.86
+	Hs
		716823 CTNB1_HUMAN (1-781): 0: 626: 100.00		SOX6_HUMAN (120-515): 3.34e-33: 137: 15.50
+	Mm
		776233 CTNB1_MOUSE (1-781): 0: 624: 99.87		SOX6_MOUSE (120-524): 1.87e-29: 125: 15.44
+	Hs
		554276 CTNB1_HUMAN (1-781): 0: 626: 100.00		MUC1_HUMAN (51-575): 3.35e-25: 113: 10.61
+	Hs
		716868 CTNB1_HUMAN (1-781): 0: 626: 100.00		SOX2_HUMAN (319-534): 6.77e-24: 104: 20.64
+	Dr
		1225024 Q8JID2_DANRE (1-781): 0: 570: 94.75		Q9W7C0_DANRE (31-444): 3.94e-27: 115: 45.00
+	Hs
		542455 PLAK_HUMAN (8-752): 2.69e-158: 479: 67.42		TF7L2_HUMAN (37-586): 6.17e-51: 187: 50.58
+	Dm
		578667 ARM_DROME (1-780): 9.15e-160: 486: 64.49		PANG2_DROME (180-579): 4.15e-41: 162: 27.06
+	Dm
		578629 ARM_DROME (1-780): 9.15e-160: 486: 64.49		PANG1_DROME (27-579): 1.5e-33: 138: 28.30
+	Hs
		542421 PLAK_HUMAN (8-752): 2.69e-158: 479: 67.42		CIC_HUMAN (72-573): 3.52e-35: 144: 13.53
+	Hs
		542475 PLAK_HUMAN (8-752): 2.69e-158: 479: 67.42		LEF1_HUMAN (31-444): 3.38e-36: 141: 47.86
+	Hs
		542170 PLAK_HUMAN (8-752): 2.69e-158: 479: 67.42		MUC1_HUMAN (51-575): 3.35e-25: 113: 10.61
+	Ce
		1014329 BAR1_CAEEL (129-740): 4.72e-102: 334: 24.15		POP1_CAEEL (213-586): 1.09e-36: 143: 23.79
+	Hs
		134850 IMA3_HUMAN (198-681): 7.05e-69: 237: 14.34		SOX2_HUMAN (319-534): 6.77e-24: 104: 20.64