HitPredict

Interactor 1: CTNB1 (P35222)
Catenin beta-1 (Beta-catenin)
Gene: CTNNB1

Interactor 2: TF7L2 (Q9NQB0)
Transcription factor 7-like 2 (HMG box transcription factor 4) (T-cell-specific transcription factor 4) (T-cell factor 4) (TCF-4) (hTCF-4)
Gene: TCF7L2

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.98 1.00 0.992

The method score is based on:

Property Details
Experiments 22155184, 11713475, 16230076, 27902311, 27684187, 30918250, 34079125, 21670201, 16630820, 17050667, 26350900, 22304967, 30833792, 33903093, 19304756, 17283121, 19443654, 16569639, 19202075, 20126258 and 10 others

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Identification Methods affinity chromatography technology, x-ray crystallography, proximity labelling technology, pull down, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, solid phase assay, coimmunoprecipitation
Interaction Type physical association, association, direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains Arm~CTNNB1_binding, Arm~HMG_box
Common GO terms GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0010718 - positive regulation of epithelial to mesenchymal transition
GO:0010909 - positive regulation of heparan sulfate proteoglycan biosynthetic process
and 12 others

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Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 781
Hs

1 619
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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024