HitPredict - High confidence protein-protein interactions

Interactor 1: CTNB1 (P35222)
Catenin beta-1 (Beta-catenin)
Gene: CTNNB1

Interactor 2: AXIN2 (Q9Y2T1)
Axin-2 (Axin-like protein) (Axil) (Axis inhibition protein 2) (Conductin)
Gene: AXIN2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.75	1.00	0.867

Property	Details
Experiments	27684187, 10966653, 22056988, 17510365
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Arm~Axin_b-cat_bind
Common GO terms	GO:0001649 - osteoblast differentiation GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005813 - centrosome GO:0005829 - cytosol and 13 others more... GO:0005886 - plasma membrane GO:0009950 - dorsal/ventral axis specification GO:0010718 - positive regulation of epithelial to mesenchymal transition GO:0019899 - enzyme binding GO:0019901 - protein kinase binding GO:0030877 - beta-catenin destruction complex GO:0031625 - ubiquitin protein ligase binding GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process GO:0060070 - canonical Wnt signaling pathway GO:0070411 - I-SMAD binding GO:0070602 - regulation of centromeric sister chromatid cohesion GO:0072089 - stem cell proliferation GO:0090090 - negative regulation of canonical Wnt signaling pathway
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1	781
Hs

1	843

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024