HitPredict

Interactor 1: BMI1 (P35226)
Polycomb complex protein BMI-1 (Polycomb group RING finger protein 4) (RING finger protein 51)
Gene: BMI1

Interactor 2: UBC9 (P63279)
SUMO-conjugating enzyme UBC9 (EC 2.3.2.-) (RING-type E3 SUMO transferase UBC9) (SUMO-protein ligase) (Ubiquitin carrier protein 9) (Ubiquitin carrier protein I) (Ubiquitin-conjugating enzyme E2 I) (Ubiquitin-protein ligase I) (p18)
Gene: UBE2I

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.48	1.00	0.698

Property	Details
Experiments	19549727
Identification Methods	two hybrid, two hybrid array
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	UQ_con~zf-C3HC4_2
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0071535 - RING-like zinc finger domain binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 326 Hs			1 158
+	Hs
		717650 BMI1_HUMAN (1-326): 1.43e-153: 435: 100.00		UB2D2_HUMAN (4-157): 2.44e-74: 220: 35.07
+	Hs
		717615 BMI1_HUMAN (1-326): 1.43e-153: 435: 100.00		UB2D3_HUMAN (4-157): 6.67e-73: 216: 35.07
+	Hs
		718384 PCGF2_HUMAN (1-320): 1.04e-117: 344: 61.36		UB2D3_HUMAN (4-157): 6.67e-73: 216: 35.07
+	Hs
		718387 PCGF2_HUMAN (1-320): 1.04e-117: 344: 61.36		UBC9_HUMAN (1-158): 1.43e-70: 211: 100.00
+	Hs
		718419 PCGF2_HUMAN (1-320): 1.04e-117: 344: 61.36		UB2E2_HUMAN (3-156): 7.29e-69: 208: 33.77
+	Hs
		895802 PCGF3_HUMAN (4-228): 4.43e-72: 225: 34.03		UB2D3_HUMAN (4-157): 6.67e-73: 216: 35.07
+	Hs
		1108530 PCGF3_HUMAN (4-228): 4.43e-72: 225: 34.03		UB2E3_HUMAN (3-156): 2.14e-68: 207: 33.77
+	Hs
		895898 PCGF6_HUMAN (2-235): 2.13e-61: 201: 35.12		UB2D3_HUMAN (4-157): 6.67e-73: 216: 35.07
+	Hs
		895893 PCGF1_HUMAN (2-229): 5.96e-62: 199: 36.33		UB2D3_HUMAN (4-157): 6.67e-73: 216: 35.07
+	Hs
		584907 RO52_HUMAN (5-198): 5.75e-52: 180: 18.78		UB2D1_HUMAN (4-157): 7.96e-75: 221: 33.12
+	Hs
		584923 RO52_HUMAN (5-198): 5.75e-52: 180: 18.78		UB2D2_HUMAN (4-157): 2.44e-74: 220: 35.07
+	Hs
		895830 PCGF5_HUMAN (1-228): 9.27e-56: 183: 30.44		UB2D3_HUMAN (4-157): 6.67e-73: 216: 35.07
+	Hs
		584916 RO52_HUMAN (5-198): 5.75e-52: 180: 18.78		UB2D3_HUMAN (4-157): 6.67e-73: 216: 35.07
+	Hs
		849314 TRI26_HUMAN (5-210): 1e-49: 175: 16.59		UB2D1_HUMAN (4-157): 7.96e-75: 221: 33.12
+	Hs
		849366 TRI22_HUMAN (1-198): 2.92e-50: 175: 14.56		UB2D1_HUMAN (4-157): 7.96e-75: 221: 33.12
+	Hs
		584994 RO52_HUMAN (5-198): 5.75e-52: 180: 18.78		Q7KZS0_HUMAN (1-137): 2.27e-71: 214: 100.00
+	Hs
		584926 RO52_HUMAN (5-198): 5.75e-52: 180: 18.78		UBC9_HUMAN (1-158): 1.43e-70: 211: 100.00
+	Hs
		895782 TRI26_HUMAN (5-210): 1e-49: 175: 16.59		UB2D3_HUMAN (4-157): 6.67e-73: 216: 35.07
+	Hs
		851832 PCGF5_HUMAN (1-228): 9.27e-56: 183: 30.44		UB2E1_HUMAN (3-156): 7.23e-67: 203: 33.12
+	Hs
		584910 RO52_HUMAN (5-198): 5.75e-52: 180: 18.78		UB2E1_HUMAN (3-156): 7.23e-67: 203: 33.12