HitPredict

Interactor 1: BMI1 (P35226)
Polycomb complex protein BMI-1 (Polycomb group RING finger protein 4) (RING finger protein 51)
Gene: BMI1

Interactor 2: TADBP (Q13148)
TAR DNA-binding protein 43 (TDP-43)
Gene: TARDBP

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.54	0.60	0.571

Property	Details
Experiments	24457600, 34316702
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0010468 - regulation of gene expression
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 326 Hs			1 414
+	Hs
		161972 BMI1_HUMAN (1-326): 1.43e-153: 435: 100.00		HNRDL_HUMAN (62-376): 5.62e-71: 231: 23.60
+	Hs
		717586 BMI1_HUMAN (1-326): 1.43e-153: 435: 100.00		ROA3_HUMAN (98-269): 2.33e-69: 225: 28.57
+	Hs
		474007 BMI1_HUMAN (1-326): 1.43e-153: 435: 100.00		PAB4L_HUMAN (2-276): 8.18e-56: 189: 16.96
+	Hs
		717893 BMI1_HUMAN (1-326): 1.43e-153: 435: 100.00		PAP1L_HUMAN (96-274): 7.74e-38: 146: 17.74
+	Hs
		680423 BMI1_HUMAN (1-326): 1.43e-153: 435: 100.00		TIA1_HUMAN (99-413): 2.4e-38: 144: 13.76
+	Hs
		717783 BMI1_HUMAN (1-326): 1.43e-153: 435: 100.00		PABP4_HUMAN (98-274): 3.77e-37: 144: 19.02
+	Hs
		516378 BMI1_HUMAN (1-326): 1.43e-153: 435: 100.00		PABP1_HUMAN (2-382): 7.78e-31: 126: 15.95
+	Hs
		718193 BMI1_HUMAN (1-326): 1.43e-153: 435: 100.00		PABP3_HUMAN (2-382): 7.84e-31: 126: 16.41
+	Hs
		717807 BMI1_HUMAN (1-326): 1.43e-153: 435: 100.00		HNRPD_HUMAN (81-238): 5.59e-21: 95.1: 35.93
+	Hs
		718090 BMI1_HUMAN (1-326): 1.43e-153: 435: 100.00		MSI2H_HUMAN (41-207): 5.16e-20: 92.2: 23.81
+	Hs
		1025923 RING2_HUMAN (7-227): 8.37e-50: 170: 16.61		TADBP_HUMAN (1-414): 4.24e-84: 264: 100.00
+	Hs
		162122 RING2_HUMAN (7-227): 8.37e-50: 170: 16.61		HNRDL_HUMAN (62-376): 5.62e-71: 231: 23.60
+	Hs
		852142 RING2_HUMAN (7-227): 8.37e-50: 170: 16.61		ROA3_HUMAN (98-269): 2.33e-69: 225: 28.57
+	Hs
		1031435 RING2_HUMAN (7-227): 8.37e-50: 170: 16.61		PABP4_HUMAN (98-274): 3.77e-37: 144: 19.02
+	Hs
		1288212 RING2_HUMAN (7-227): 8.37e-50: 170: 16.61		MSI2H_HUMAN (41-207): 5.16e-20: 92.2: 23.81
+	Hs
		282502 RNF8_HUMAN (2-101): 3.38e-21: 95.7: 25.00		PABP1_HUMAN (2-382): 7.78e-31: 126: 15.95
+	Hs
		282649 RNF8_HUMAN (2-101): 3.38e-21: 95.7: 25.00		HNRPD_HUMAN (81-238): 5.59e-21: 95.1: 35.93