HitPredict

Interactor 1: BMI1 (P35226)
Polycomb complex protein BMI-1 (Polycomb group RING finger protein 4) (RING finger protein 51)
Gene: BMI1

Interactor 2: CBX3 (Q13185)
Chromobox protein homolog 3 (HECH) (Heterochromatin protein 1 homolog gamma) (HP1 gamma) (Modifier 2 protein)
Gene: CBX3

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	27647897, 24981860
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0000792 - heterochromatin GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006338 - chromatin remodeling
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 326 Hs			1 183
+	Hs
		717529 BMI1_HUMAN (1-326): 1.43e-153: 435: 100.00		CBX5_HUMAN (11-182): 1.62e-55: 175: 59.89
+	Hs
		718395 PCGF2_HUMAN (1-320): 1.04e-117: 344: 61.36		CBX3_HUMAN (1-183): 1.62e-71: 215: 100.00
+	Hs
		327830 BMI1_HUMAN (1-326): 1.43e-153: 435: 100.00		CBX7_HUMAN (21-181): 5.6e-29: 109: 22.78
+	Hs
		123193 BMI1_HUMAN (1-326): 1.43e-153: 435: 100.00		CBX4_HUMAN (21-121): 4.95e-27: 108: 29.52
+	Hs
		315976 BMI1_HUMAN (1-326): 1.43e-153: 435: 100.00		CBX6_HUMAN (21-124): 3.3e-27: 107: 27.78
+	Hs
		718213 BMI1_HUMAN (1-326): 1.43e-153: 435: 100.00		CBX8_HUMAN (21-116): 2.34e-26: 104: 32.00
+	Hs
		717831 BMI1_HUMAN (1-326): 1.43e-153: 435: 100.00		CBX2_HUMAN (20-117): 5.97e-25: 102: 27.00
+	Mm
		639481 BMI1_MOUSE (1-326): 2.15e-150: 426: 96.93		CBX8_MOUSE (21-116): 1.13e-26: 105: 32.00
+	Mm
		639466 BMI1_MOUSE (1-326): 2.15e-150: 426: 96.93		CBX2_MOUSE (20-117): 6.27e-26: 104: 27.00
+	Dr
		1193374 BMI1A_DANRE (1-326): 9.35e-128: 369: 81.29		Q804D1_DANRE (21-106): 6.82e-25: 101: 31.11
+	Dr
		1186372 BMI1B_DANRE (1-322): 4e-124: 360: 77.23		Q804D1_DANRE (21-106): 6.82e-25: 101: 31.11
+	Hs
		327831 PCGF2_HUMAN (1-320): 1.04e-117: 344: 61.36		CBX7_HUMAN (21-181): 5.6e-29: 109: 22.78
+	Hs
		123194 PCGF2_HUMAN (1-320): 1.04e-117: 344: 61.36		CBX4_HUMAN (21-121): 4.95e-27: 108: 29.52
+	Hs
		315977 PCGF2_HUMAN (1-320): 1.04e-117: 344: 61.36		CBX6_HUMAN (21-124): 3.3e-27: 107: 27.78
+	Hs
		718431 PCGF2_HUMAN (1-320): 1.04e-117: 344: 61.36		CBX8_HUMAN (21-116): 2.34e-26: 104: 32.00
+	Hs
		718398 PCGF2_HUMAN (1-320): 1.04e-117: 344: 61.36		CBX2_HUMAN (20-117): 5.97e-25: 102: 27.00
+	Mm
		223225 PCGF2_MOUSE (1-320): 5.49e-113: 332: 61.06		CBX4_MOUSE (21-121): 3.91e-27: 108: 29.52
+	Mm
		620795 PCGF2_MOUSE (1-320): 5.49e-113: 332: 61.06		CBX8_MOUSE (21-116): 1.13e-26: 105: 32.00
+	Mm
		620782 PCGF2_MOUSE (1-320): 5.49e-113: 332: 61.06		CBX2_MOUSE (20-117): 6.27e-26: 104: 27.00
+	Mm
		620791 PCGF2_MOUSE (1-320): 5.49e-113: 332: 61.06		CBX7_MOUSE (21-101): 5.72e-26: 99.1: 35.29