HitPredict

Interactor 1: PCGF2 (P35227)
Polycomb group RING finger protein 2 (DNA-binding protein Mel-18) (RING finger protein 110) (Zinc finger protein 144)
Gene: PCGF2

Interactor 2: CBX2 (Q14781)
Chromobox protein homolog 2
Gene: CBX2

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.94	1.00	0.972

Property	Details
Experiments	31093962, 24981860, 37014752, 28514442, 27705803, 33961781, 19636380, 22325352, 20601937
Identification Methods	pull down, affinity chromatography technology, anti tag coimmunoprecipitation, tandem affinity purification
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	CBX7_C~RAWUL
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0003677 - DNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0031519 - PcG protein complex and 1 others more... GO:0035102 - PRC1 complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 344 Hs			1 532
+	Mm
		620782 PCGF2_MOUSE (1-342): 3.16e-110: 326: 95.91		CBX2_MOUSE (1-532): 1.26e-145: 430: 81.84
+	Hs
		717831 BMI1_HUMAN (1-341): 3.88e-98: 295: 61.40		CBX2_HUMAN (1-532): 6.32e-156: 457: 100.00
+	Mm
		639466 BMI1_MOUSE (1-341): 4.26e-96: 290: 61.11		CBX2_MOUSE (1-532): 1.26e-145: 430: 81.84
+	Hs
		123194 PCGF2_HUMAN (1-344): 8.96e-118: 345: 100.00		CBX4_HUMAN (3-522): 6.17e-110: 340: 21.89
+	Mm
		223225 PCGF2_MOUSE (1-342): 3.16e-110: 326: 95.91		CBX4_MOUSE (3-522): 1.1e-116: 357: 22.28
+	Hs
		123193 BMI1_HUMAN (1-341): 3.88e-98: 295: 61.40		CBX4_HUMAN (3-522): 6.17e-110: 340: 21.89
+	Dr
		1193374 BMI1A_DANRE (1-340): 1.28e-94: 286: 61.77		Q804D1_DANRE (3-521): 3.29e-99: 310: 24.04
+	Hs
		315977 PCGF2_HUMAN (1-344): 8.96e-118: 345: 100.00		CBX6_HUMAN (3-242): 2.28e-36: 141: 30.29
+	Hs
		718431 PCGF2_HUMAN (1-344): 8.96e-118: 345: 100.00		CBX8_HUMAN (3-238): 1.39e-35: 139: 29.39
+	Hs
		718395 PCGF2_HUMAN (1-344): 8.96e-118: 345: 100.00		CBX3_HUMAN (9-152): 1.29e-37: 138: 21.53
+	Hs
		327831 PCGF2_HUMAN (1-344): 8.96e-118: 345: 100.00		CBX7_HUMAN (3-210): 1.4e-35: 135: 27.98
+	Mm
		620795 PCGF2_MOUSE (1-342): 3.16e-110: 326: 95.91		CBX8_MOUSE (3-238): 1.64e-38: 146: 31.75
+	Hs
		718131 BMI1_HUMAN (1-341): 3.88e-98: 295: 61.40		MPP8_HUMAN (7-397): 6.88e-47: 177: 17.54
+	Mm
		620791 PCGF2_MOUSE (1-342): 3.16e-110: 326: 95.91		CBX7_MOUSE (3-117): 1.22e-29: 115: 42.24
+	Hs
		315976 BMI1_HUMAN (1-341): 3.88e-98: 295: 61.40		CBX6_HUMAN (3-242): 2.28e-36: 141: 30.29
+	Mm
		639481 BMI1_MOUSE (1-341): 4.26e-96: 290: 61.11		CBX8_MOUSE (3-238): 1.64e-38: 146: 31.75
+	Hs
		718213 BMI1_HUMAN (1-341): 3.88e-98: 295: 61.40		CBX8_HUMAN (3-238): 1.39e-35: 139: 29.39
+	Hs
		717776 BMI1_HUMAN (1-341): 3.88e-98: 295: 61.40		CBX3_HUMAN (9-152): 1.29e-37: 138: 21.53
+	Hs
		327830 BMI1_HUMAN (1-341): 3.88e-98: 295: 61.40		CBX7_HUMAN (3-210): 1.4e-35: 135: 27.98
+	Hs
		717529 BMI1_HUMAN (1-341): 3.88e-98: 295: 61.40		CBX5_HUMAN (12-152): 1.24e-35: 133: 24.66