HitPredict

Interactor 1: PCGF2 (P35227)
Polycomb group RING finger protein 2 (DNA-binding protein Mel-18) (RING finger protein 110) (Zinc finger protein 144)
Gene: PCGF2

Interactor 2: H2B2E (Q16778)
Histone H2B type 2-E (H2B-clustered histone 21) (Histone H2B-GL105) (Histone H2B.q) (H2B/q)
Gene: H2BC21

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	35271311
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Histone~zf-C3HC4_2
Common GO terms	GO:0003677 - DNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 344 Hs			1 126
+	Hs
		717646 BMI1_HUMAN (1-341): 3.88e-98: 295: 61.40		H2B1C_HUMAN (1-126): 1.18e-53: 166: 99.21
+	Hs
		717877 BMI1_HUMAN (1-341): 3.88e-98: 295: 61.40		H2B2E_HUMAN (1-126): 6.69e-54: 166: 100.00
+	Hs
		707534 BMI1_HUMAN (1-341): 3.88e-98: 295: 61.40		H2B1B_HUMAN (1-126): 1.74e-53: 165: 98.41
+	Hs
		717607 BMI1_HUMAN (1-341): 3.88e-98: 295: 61.40		H2B1D_HUMAN (1-126): 3.5e-53: 164: 98.41
+	Hs
		1087375 PCGF1_HUMAN (2-232): 1.01e-61: 199: 35.42		H2B2E_HUMAN (1-126): 6.69e-54: 166: 100.00
+	Hs
		918649 PCGF1_HUMAN (2-232): 1.01e-61: 199: 35.42		H2B1C_HUMAN (1-126): 1.18e-53: 166: 99.21
+	Hs
		1087359 RING2_HUMAN (4-234): 2.68e-45: 159: 17.49		H2B2E_HUMAN (1-126): 6.69e-54: 166: 100.00
+	Hs
		918631 RING2_HUMAN (4-234): 2.68e-45: 159: 17.49		H2B1C_HUMAN (1-126): 1.18e-53: 166: 99.21
+	Hs
		707723 RING2_HUMAN (4-234): 2.68e-45: 159: 17.49		H2B1B_HUMAN (1-126): 1.74e-53: 165: 98.41
+	Hs
		1231231 RING2_HUMAN (4-234): 2.68e-45: 159: 17.49		H2B3B_HUMAN (1-126): 1.01e-51: 161: 96.03
+	Mm
		1145466 CHFR_MOUSE (7-150): 2.39e-29: 120: 17.81		H2B2E_MOUSE (1-126): 1.28e-52: 163: 96.83
+	Hs
		918311 RING1_HUMAN (3-127): 4.75e-28: 114: 23.26		H2B1C_HUMAN (1-126): 1.18e-53: 166: 99.21
+	Hs
		707600 RING1_HUMAN (3-127): 4.75e-28: 114: 23.26		H2B1B_HUMAN (1-126): 1.74e-53: 165: 98.41
+	Hs
		282669 RNF8_HUMAN (2-101): 6.37e-23: 101: 25.00		H2B2E_HUMAN (1-126): 6.69e-54: 166: 100.00
+	Hs
		282550 RNF8_HUMAN (2-101): 6.37e-23: 101: 25.00		H2B1B_HUMAN (1-126): 1.74e-53: 165: 98.41
+	Mm
		1145467 RNF8_MOUSE (2-107): 1.18e-22: 100: 25.47		H2B2E_MOUSE (1-126): 1.28e-52: 163: 96.83