HitPredict

Interactor 1: PCGF2 (P35227)
Polycomb group RING finger protein 2 (DNA-binding protein Mel-18) (RING finger protein 110) (Zinc finger protein 144)
Gene: PCGF2

Interactor 2: PCGF3 (Q3KNV8)
Polycomb group RING finger protein 3 (RING finger protein 3A)
Gene: PCGF3

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	24981860
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	RAWUL~RAWUL, zf-C3HC4_2~zf-C3HC4_2
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0031519 - PcG protein complex GO:0035102 - PRC1 complex GO:0046872 - metal ion binding
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 344 Hs			1 242
+	Hs
		717489 PCGF2_HUMAN (1-344): 8.96e-118: 345: 100.00		BMI1_HUMAN (3-238): 2.96e-60: 194: 33.76
+	Hs
		718376 PCGF2_HUMAN (1-344): 8.96e-118: 345: 100.00		PCGF2_HUMAN (3-238): 5.76e-59: 191: 34.03
+	Mm
		620781 PCGF2_MOUSE (1-342): 3.16e-110: 326: 95.91		PCGF2_MOUSE (3-238): 2.56e-56: 184: 34.18
+	Hs
		717887 BMI1_HUMAN (1-341): 3.88e-98: 295: 61.40		PCGF3_HUMAN (1-242): 8.16e-66: 205: 100.00
+	Hs
		718422 PCGF2_HUMAN (1-344): 8.96e-118: 345: 100.00		PCGF1_HUMAN (3-238): 1.66e-45: 154: 38.33
+	Hs
		718424 PCGF2_HUMAN (1-344): 8.96e-118: 345: 100.00		PCGF6_HUMAN (3-235): 4.63e-43: 150: 33.62
+	Hs
		717488 BMI1_HUMAN (1-341): 3.88e-98: 295: 61.40		BMI1_HUMAN (3-238): 2.96e-60: 194: 33.76
+	Hs
		718406 PCGF2_HUMAN (1-344): 8.96e-118: 345: 100.00		PCGF5_HUMAN (4-241): 3.95e-40: 140: 38.06
+	Hs
		718420 PCGF2_HUMAN (1-344): 8.96e-118: 345: 100.00		RING2_HUMAN (2-237): 3.42e-36: 132: 18.00
+	Hs
		718393 PCGF2_HUMAN (1-344): 8.96e-118: 345: 100.00		RING1_HUMAN (3-172): 3.16e-35: 131: 20.81
+	Mm
		193403 PCGF2_MOUSE (1-342): 3.16e-110: 326: 95.91		RING1_MOUSE (3-182): 7.06e-36: 133: 20.22
+	Mm
		620793 PCGF2_MOUSE (1-342): 3.16e-110: 326: 95.91		RING2_MOUSE (2-237): 2.47e-36: 132: 18.00
+	Hs
		718150 BMI1_HUMAN (1-341): 3.88e-98: 295: 61.40		PCGF1_HUMAN (3-238): 1.66e-45: 154: 38.33
+	Hs
		988039 R4GMX3_HUMAN (1-341): 1.22e-101: 308: 61.40		RING1_HUMAN (3-172): 3.16e-35: 131: 20.81
+	Hs
		717977 BMI1_HUMAN (1-341): 3.88e-98: 295: 61.40		PCGF5_HUMAN (4-241): 3.95e-40: 140: 38.06
+	Hs
		718129 BMI1_HUMAN (1-341): 3.88e-98: 295: 61.40		RING2_HUMAN (2-237): 3.42e-36: 132: 18.00
+	Hs
		717742 BMI1_HUMAN (1-341): 3.88e-98: 295: 61.40		RING1_HUMAN (3-172): 3.16e-35: 131: 20.81
+	Hs
		536741 BMI1_HUMAN (1-341): 3.88e-98: 295: 61.40		TRI27_HUMAN (2-237): 2.45e-31: 122: 12.06
+	Hs
		717765 BMI1_HUMAN (1-341): 3.88e-98: 295: 61.40		TRI26_HUMAN (2-208): 2.66e-31: 122: 15.28