HitPredict

Interactor 1: PCGF2 (P35227)
Polycomb group RING finger protein 2 (DNA-binding protein Mel-18) (RING finger protein 110) (Zinc finger protein 144)
Gene: PCGF2

Interactor 2: YAF2 (Q8IY57)
YY1-associated factor 2
Gene: YAF2

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.89	1.00	0.945

Property	Details
Experiments	28514442, 27705803, 33961781, 22325352, 24981860, 20601937
Identification Methods	affinity chromatography technology, tandem affinity purification, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	RAWUL~YAF2_RYBP
Common GO terms	GO:0003677 - DNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0046872 - metal ion binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 344 Hs			1 180
+	Hs
		718000 BMI1_HUMAN (1-341): 3.88e-98: 295: 61.40		YAF2_HUMAN (1-180): 8.51e-73: 218: 100.00
+	Hs
		718410 PCGF2_HUMAN (1-344): 8.96e-118: 345: 100.00		RYBP_HUMAN (1-179): 5.8e-49: 160: 49.78
+	Mm
		620789 PCGF2_MOUSE (1-342): 3.16e-110: 326: 95.91		RYBP_MOUSE (1-179): 3.52e-49: 160: 49.78
+	Hs
		718013 BMI1_HUMAN (1-341): 3.88e-98: 295: 61.40		RYBP_HUMAN (1-179): 5.8e-49: 160: 49.78
+	Hs
		1108516 PCGF3_HUMAN (4-230): 3.51e-66: 210: 33.48		YAF2_HUMAN (1-180): 8.51e-73: 218: 100.00
+	Hs
		1222217 PCGF1_HUMAN (2-232): 1.01e-61: 199: 35.42		YAF2_HUMAN (1-180): 8.51e-73: 218: 100.00
+	Hs
		1222219 PCGF6_HUMAN (2-227): 3.54e-58: 193: 35.47		YAF2_HUMAN (1-180): 8.51e-73: 218: 100.00
+	Hs
		1197569 PCGF5_HUMAN (1-221): 5.43e-53: 177: 31.88		YAF2_HUMAN (1-180): 8.51e-73: 218: 100.00
+	Mm
		1307837 RING2_MOUSE (4-234): 2.19e-45: 159: 17.49		YAF2_MOUSE (1-180): 3.8e-76: 227: 91.67
+	Hs
		1222214 RING2_HUMAN (4-234): 2.68e-45: 159: 17.49		YAF2_HUMAN (1-180): 8.51e-73: 218: 100.00
+	Dm
		627173 SUZ2_DROME (8-331): 1.57e-61: 214: 26.91		Q9W215_DROME (1-133): 1.35e-51: 163: 51.13
+	Dm
		728817 PSC_DROME (3-344): 1.47e-61: 214: 31.91		Q9W215_DROME (1-133): 1.35e-51: 163: 51.13
+	Hs
		1108517 PCGF3_HUMAN (4-230): 3.51e-66: 210: 33.48		RYBP_HUMAN (1-179): 5.8e-49: 160: 49.78
+	Hs
		1233178 PCGF1_HUMAN (2-232): 1.01e-61: 199: 35.42		RYBP_HUMAN (1-179): 5.8e-49: 160: 49.78
+	Mm
		1208119 PCGF1_MOUSE (2-232): 4.4e-61: 197: 35.83		RYBP_MOUSE (1-179): 3.52e-49: 160: 49.78
+	Hs
		1233190 PCGF6_HUMAN (2-227): 3.54e-58: 193: 35.47		RYBP_HUMAN (1-179): 5.8e-49: 160: 49.78
+	Dm
		1374687 Q9VV77_DROME (4-230): 3.72e-58: 189: 34.19		Q9W215_DROME (1-133): 1.35e-51: 163: 51.13
+	Mm
		1208122 PCGF6_MOUSE (2-227): 6.81e-55: 184: 35.04		RYBP_MOUSE (1-179): 3.52e-49: 160: 49.78
+	Hs
		1197570 PCGF5_HUMAN (1-221): 5.43e-53: 177: 31.88		RYBP_HUMAN (1-179): 5.8e-49: 160: 49.78
+	Mm
		1208123 RING2_MOUSE (4-234): 2.19e-45: 159: 17.49		RYBP_MOUSE (1-179): 3.52e-49: 160: 49.78