Interactor 1: NOS2 (P35228)
Nitric oxide synthase, inducible (EC 1.14.13.39) (Hepatocyte NOS) (HEP-NOS) (Inducible NO synthase) (Inducible NOS) (iNOS) (NOS type II) (Peptidyl-cysteine S-nitrosylase NOS2)
Gene: NOS2

Interactor 2: NOS2 (P35228)
Nitric oxide synthase, inducible (EC 1.14.13.39) (Hepatocyte NOS) (HEP-NOS) (Inducible NO synthase) (Inducible NOS) (iNOS) (NOS type II) (Peptidyl-cysteine S-nitrosylase NOS2)
Gene: NOS2

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.90 1.00 0.952

The method score is based on:

Property Details
Experiments 11517317, 19737939, 23438482, 10074942, 18849972, 19364813, 14614131
Identification Methods biochemical, x-ray crystallography, pull down, affinity chromatography technology, anti tag coimmunoprecipitation, comigration in gel electrophoresis
Interaction Type association, direct interaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains FAD_binding_1~FAD_binding_1, FAD_binding_1~Flavodoxin_1, FAD_binding_1~NAD_binding_1, Flavodoxin_1~Flavodoxin_1, Flavodoxin_1~NAD_binding_1, NAD_binding_1~NAD_binding_1, NO_synthase~NO_synthase
Common GO terms GO:0001666 - response to hypoxia
GO:0001912 - positive regulation of leukocyte mediated cytotoxicity
GO:0002227 - innate immune response in mucosa
GO:0004517 - nitric-oxide synthase activity
GO:0005516 - calmodulin binding
and 44 others

more...

Homologous interactions 9

Homologous interactions

Color coding for hit scores

1 1153
Hs

1 1153
+ Mm
+ Hs
+ Hs
+ Bt
+ Hs
+ Dm
+ Hs
+ Hs
+ Ec

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Last updated: 15 Jul 2024