HitPredict

Interactor 1: PHB1 (P35232)
Prohibitin 1
Gene: PHB1

Interactor 2: XIAP (P98170)
E3 ubiquitin-protein ligase XIAP (EC 2.3.2.27) (Baculoviral IAP repeat-containing protein 4) (IAP-like protein) (ILP) (hILP) (Inhibitor of apoptosis protein 3) (IAP-3) (hIAP-3) (hIAP3) (RING-type E3 ubiquitin transferase XIAP) (X-linked inhibitor of apoptosis protein) (X-linked IAP)
Gene: XIAP

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.67	0.60	0.634

Property	Details
Experiments	27025967, 33961781
Identification Methods	affinity chromatography technology, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0042981 - regulation of apoptotic process
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 272 Hs			1 497
+	Hs
		957770 PHB2_HUMAN (6-267): 1.38e-85: 259: 50.57		XIAP_HUMAN (1-497): 0: 569: 100.00
+	Hs
		718828 PHB1_HUMAN (1-272): 7.06e-92: 274: 100.00		BIRC2_HUMAN (3-497): 9.73e-82: 267: 23.31
+	Hs
		718827 PHB1_HUMAN (1-272): 7.06e-92: 274: 100.00		BIRC3_HUMAN (150-394): 2.89e-41: 158: 23.94
+	Hs
		1036004 PHB2_HUMAN (6-267): 1.38e-85: 259: 50.57		BIRC3_HUMAN (150-394): 2.89e-41: 158: 23.94
+	Hs
		1305280 PHB2_HUMAN (6-267): 1.38e-85: 259: 50.57		BIRC6_HUMAN (258-442): 3.1e-26: 115: 18.78
+	Hs
		646288 STOM_HUMAN (1-265): 6.57e-68: 213: 17.91		RNF26_HUMAN (320-496): 6.59e-25: 108: 14.13