Interactor 1: MERL (P35240)
Merlin (Moesin-ezrin-radixin-like protein) (Neurofibromin-2) (Schwannomerlin) (Schwannomin)
Gene: NF2

Interactor 2: MERL (P35240)
Merlin (Moesin-ezrin-radixin-like protein) (Neurofibromin-2) (Schwannomerlin) (Schwannomin)
Gene: NF2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.86 1.00 0.930

The method score is based on:

Property Details
Experiments 24012335, 28205554, 11856822, 28514442, 11779178, 9537418
Identification Methods affinity chromatography technology, fluorescent resonance energy transfer, x-ray crystallography, anti tag coimmunoprecipitation, two hybrid
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains ERM_C~ERM_C, ERM_C~FERM_C, ERM_C~FERM_M, ERM_helical~FERM_N, FERM_C~FERM_C, FERM_C~FERM_M, FERM_C~FERM_N, FERM_M~FERM_M, FERM_M~FERM_N, FERM_N~FERM_N
Common GO terms GO:0000165 - MAPK cascade
GO:0001707 - mesoderm formation
GO:0001953 - negative regulation of cell-matrix adhesion
GO:0003779 - actin binding
GO:0005178 - integrin binding
and 49 others

more...

Homologous interactions 15

Homologous interactions

Color coding for hit scores

1 595
Hs

1 595
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+ Dm
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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024