HitPredict

Interactor 1: MERL (P35240)
Merlin (Moesin-ezrin-radixin-like protein) (Neurofibromin-2) (Schwannomerlin) (Schwannomin)
Gene: NF2

Interactor 2: CDN2C (P42773)
Cyclin-dependent kinase 4 inhibitor C (Cyclin-dependent kinase 6 inhibitor) (p18-INK4c) (p18-INK6)
Gene: CDKN2C

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	28205554
Identification Methods	fluorescent resonance energy transfer
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0008285 - negative regulation of cell population proliferation
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 595 Hs			1 168
+	Hs
		547272 EZRI_HUMAN (19-595): 8.21e-152: 450: 44.20		KDIS_HUMAN (2-159): 8.8e-46: 161: 26.42
+	Hs
		719429 MERL_HUMAN (1-595): 1.12e-172: 504: 100.00		RIPK4_HUMAN (1-99): 1.47e-26: 106: 28.00
+	Hs
		719403 MERL_HUMAN (1-595): 1.12e-172: 504: 100.00		CDN2B_HUMAN (9-122): 1.23e-20: 84: 45.22
+	Hs
		547253 EZRI_HUMAN (19-595): 8.21e-152: 450: 44.20		RAI14_HUMAN (1-135): 3.41e-37: 136: 21.32
+	Hs
		719780 RADI_HUMAN (19-595): 5.41e-151: 448: 45.47		RAI14_HUMAN (1-135): 3.41e-37: 136: 21.32
+	Hs
		547029 EZRI_HUMAN (19-595): 8.21e-152: 450: 44.20		ANK3_HUMAN (77-168): 3.08e-25: 103: 41.30
+	Hs
		547010 EZRI_HUMAN (19-595): 8.21e-152: 450: 44.20		ANK2_HUMAN (77-168): 1.26e-23: 98.4: 40.22
+	Hs
		1336475 E41LA_HUMAN (19-416): 3.96e-121: 375: 24.46		KDIS_HUMAN (2-159): 8.8e-46: 161: 26.42
+	Hs
		640286 PTN3_HUMAN (3-433): 3.81e-115: 366: 22.52		KDIS_HUMAN (2-159): 8.8e-46: 161: 26.42
+	Hs
		547206 EZRI_HUMAN (19-595): 8.21e-152: 450: 44.20		TANC1_HUMAN (82-168): 2.68e-12: 65.7: 22.47
+	Hs
		257705 E41L5_HUMAN (2-595): 6.77e-134: 410: 18.38		ANR17_HUMAN (3-166): 2.37e-18: 83: 20.10
+	Hs
		1219853 E41L5_HUMAN (2-595): 6.77e-134: 410: 18.38		ANKH1_HUMAN (74-166): 7.6e-18: 81.5: 22.58
+	Hs
		1206062 E41L5_HUMAN (2-595): 6.77e-134: 410: 18.38		MIB1_HUMAN (74-168): 4.43e-14: 70.7: 21.88
+	Hs
		505575 EPB41_HUMAN (3-566): 9.71e-126: 392: 19.73		CDN2A_HUMAN (3-140): 5.49e-22: 88.2: 39.57
+	Hs
		1021466 E41LA_HUMAN (19-416): 3.96e-121: 375: 24.46		ANK3_HUMAN (77-168): 3.08e-25: 103: 41.30
+	Hs
		883686 FARP1_HUMAN (2-526): 5.38e-114: 366: 18.35		RIPK4_HUMAN (1-99): 1.47e-26: 106: 28.00
+	Hs
		640287 PTN3_HUMAN (3-433): 3.81e-115: 366: 22.52		ANR50_HUMAN (51-168): 3.96e-26: 105: 28.81
+	Hs
		965179 FARP1_HUMAN (2-526): 5.38e-114: 366: 18.35		ANK2_HUMAN (77-168): 1.26e-23: 98.4: 40.22
+	Hs
		790911 FARP1_HUMAN (2-526): 5.38e-114: 366: 18.35		CDN2A_HUMAN (3-140): 5.49e-22: 88.2: 39.57
+	Hs
		1206063 E41LA_HUMAN (19-416): 3.96e-121: 375: 24.46		MIB1_HUMAN (74-168): 4.43e-14: 70.7: 21.88