HitPredict

Interactor 1: MERL (P35240)
Merlin (Moesin-ezrin-radixin-like protein) (Neurofibromin-2) (Schwannomerlin) (Schwannomin)
Gene: NF2

Interactor 2: LATS2 (Q9NRM7)
Serine/threonine-protein kinase LATS2 (EC 2.7.11.1) (Kinase phosphorylated during mitosis protein) (Large tumor suppressor homolog 2) (Serine/threonine-protein kinase kpm) (Warts-like kinase)
Gene: LATS2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.82	0.60	0.702

Property	Details
Experiments	26045165, 24012335, 28205554, 33368671, 29183995
Identification Methods	x-ray crystallography, affinity chromatography technology, fluorescent resonance energy transfer
Interaction Type	association, physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 595 Hs			1 1088
+	Hs
		325643 MERL_HUMAN (1-595): 1.12e-172: 504: 100.00		LATS1_HUMAN (1-1083): 0: 734: 49.61
+	Hs
		681692 MERL_HUMAN (1-595): 1.12e-172: 504: 100.00		AKT1_HUMAN (532-1043): 2.2e-141: 435: 22.16
+	Hs
		116966 EZRI_HUMAN (19-595): 8.21e-152: 450: 44.20		SGK1_HUMAN (608-1042): 1.07e-131: 408: 28.51
+	Dm
		1098295 MERH_DROME (12-595): 1.63e-133: 405: 45.35		WARTS_DROME (167-1039): 7.21e-137: 443: 39.71
+	Hs
		640215 PTN3_HUMAN (3-433): 3.81e-115: 366: 22.52		AKT1_HUMAN (532-1043): 2.2e-141: 435: 22.16
+	Hs
		547095 EZRI_HUMAN (19-595): 8.21e-152: 450: 44.20		MRCKA_HUMAN (656-1007): 6.11e-76: 277: 41.23
+	Hs
		1137909 E41LA_HUMAN (19-416): 3.96e-121: 375: 24.46		MRCKA_HUMAN (656-1007): 6.11e-76: 277: 41.23
+	Hs
		640223 PTN3_HUMAN (3-433): 3.81e-115: 366: 22.52		KS6A3_HUMAN (519-990): 8.69e-81: 281: 19.63
+	Hs
		640249 PTN3_HUMAN (3-433): 3.81e-115: 366: 22.52		KS6A1_HUMAN (519-977): 1.47e-79: 277: 20.34
+	Hs
		1035182 FRMD5_HUMAN (9-358): 3.53e-113: 350: 26.20		ROCK1_HUMAN (640-1008): 1.28e-70: 260: 38.77