HitPredict

Interactor 1: MERL (P35240)
Merlin (Moesin-ezrin-radixin-like protein) (Neurofibromin-2) (Schwannomerlin) (Schwannomin)
Gene: NF2

Interactor 2: AMOL2 (Q9Y2J4)
Angiomotin-like protein 2 (Leman coiled-coil protein) (LCCP)
Gene: AMOTL2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.92	0.60	0.744

Property	Details
Experiments	26549023, 33058421, 33961781, 32296183, 24255178, unassigned1304, 21481793
Identification Methods	affinity chromatography technology, two hybrid, two hybrid array, validated two hybrid, two hybrid prey pooling approach, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0030036 - actin cytoskeleton organization
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 595 Hs			1 779
+	Hs
		719515 MERL_HUMAN (1-595): 1.12e-172: 504: 100.00		AMOT_HUMAN (1-740): 2.7e-70: 252: 32.32
+	Cl
		47350 A0A8C0RSL8_CANLF (1-586): 5.48e-168: 492: 98.30		A0A8C0SSK1_CANLF (1-740): 1.53e-72: 258: 34.48
+	Hs
		57670 MERL_HUMAN (1-595): 1.12e-172: 504: 100.00		A2BDD9_HUMAN (293-740): 2.1e-43: 169: 48.73
+	Hs
		719537 MERL_HUMAN (1-595): 1.12e-172: 504: 100.00		AMOL1_HUMAN (1-766): 4.56e-42: 167: 40.22
+	Rn
		2889 MERL_RAT (5-579): 3.77e-163: 480: 97.91		A0A0G2JX94_RAT (1-661): 2.93e-37: 152: 37.37
+	Hs
		547074 EZRI_HUMAN (19-595): 8.21e-152: 450: 44.20		ITSN1_HUMAN (136-766): 1.5e-36: 150: 11.46
+	Hs
		719660 MERL_HUMAN (1-595): 1.12e-172: 504: 100.00		SMC3_HUMAN (220-710): 6.48e-09: 61.6: 14.34
+	Hs
		640054 MOES_HUMAN (19-595): 5.97e-146: 435: 44.44		MYH9_HUMAN (16-773): 4.81e-28: 123: 9.57
+	Hs
		547095 EZRI_HUMAN (19-595): 8.21e-152: 450: 44.20		MRCKA_HUMAN (242-732): 6.78e-18: 91.3: 12.33
+	Hs
		547271 EZRI_HUMAN (19-595): 8.21e-152: 450: 44.20		MYH13_HUMAN (250-769): 1.5e-17: 90.1: 9.58
+	Hs
		547232 EZRI_HUMAN (19-595): 8.21e-152: 450: 44.20		MYO5C_HUMAN (85-502): 3.91e-13: 75.5: 11.37
+	Hs
		505568 EPB41_HUMAN (3-566): 9.71e-126: 392: 19.73		MYH9_HUMAN (16-773): 4.81e-28: 123: 9.57
+	Hs
		505569 EPB41_HUMAN (3-566): 9.71e-126: 392: 19.73		MYH10_HUMAN (222-773): 1.7e-23: 109: 10.95
+	Hs
		1331065 E41L1_HUMAN (1-535): 3.42e-120: 378: 21.61		MYH4_HUMAN (27-765): 3.23e-24: 111: 10.70
+	Hs
		505542 EPB41_HUMAN (3-566): 9.71e-126: 392: 19.73		MYH1_HUMAN (348-778): 4.72e-15: 82: 10.88
+	Hs
		1137909 E41LA_HUMAN (19-416): 3.96e-121: 375: 24.46		MRCKA_HUMAN (242-732): 6.78e-18: 91.3: 12.33