HitPredict

Interactor 1: RADI (P35241)
Radixin
Gene: RDX

Interactor 2: VGFR3 (P35916)
Vascular endothelial growth factor receptor 3 (VEGFR-3) (EC 2.7.10.1) (Fms-like tyrosine kinase 4) (FLT-4) (Tyrosine-protein kinase receptor FLT4)
Gene: FLT4

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	FERM_M~PK_Tyr_Ser-Thr
Common GO terms	GO:0005886 - plasma membrane GO:0030335 - positive regulation of cell migration
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 583 Hs			1 1363
+	Hs
		640055 MOES_HUMAN (1-583): 2.8e-161: 474: 80.96		VGFR3_HUMAN (1-1363): 0: 982: 100.00
+	Hs
		665555 RADI_HUMAN (1-583): 3.49e-166: 487: 100.00		EPHB2_HUMAN (372-1320): 3.34e-154: 495: 12.87
+	Hs
		719689 RADI_HUMAN (1-583): 3.49e-166: 487: 100.00		EPHA5_HUMAN (373-1199): 1.28e-153: 493: 13.44
+	Hs
		640048 MOES_HUMAN (1-583): 2.8e-161: 474: 80.96		EPHB2_HUMAN (372-1320): 3.34e-154: 495: 12.87
+	Hs
		665554 MERL_HUMAN (2-583): 1.72e-151: 450: 45.30		EPHB2_HUMAN (372-1320): 3.34e-154: 495: 12.87
+	Hs
		434145 RADI_HUMAN (1-583): 3.49e-166: 487: 100.00		RET_HUMAN (801-1176): 1.25e-74: 273: 40.63
+	Hs
		434144 MERL_HUMAN (2-583): 1.72e-151: 450: 45.30		RET_HUMAN (801-1176): 1.25e-74: 273: 40.63
+	Hs
		557050 MERL_HUMAN (2-583): 1.72e-151: 450: 45.30		PGFRA_HUMAN (11-549): 8.68e-55: 211: 20.36
+	Hs
		609192 RADI_HUMAN (1-583): 3.49e-166: 487: 100.00		FGFR3_HUMAN (310-670): 4.9e-27: 121: 13.53
+	Hs
		546928 EZRI_HUMAN (1-583): 3.17e-166: 487: 76.28		FGFR4_HUMAN (535-810): 1.64e-14: 80.8: 15.79
+	Hs
		607901 RADI_HUMAN (1-583): 3.49e-166: 487: 100.00		FGFR4_HUMAN (535-810): 1.64e-14: 80.8: 15.79
+	Hs
		507828 EZRI_HUMAN (1-583): 3.17e-166: 487: 76.28		FGFR1_HUMAN (2-160): 6.17e-14: 78.9: 11.93
+	Hs
		507885 RADI_HUMAN (1-583): 3.49e-166: 487: 100.00		FGFR1_HUMAN (2-160): 6.17e-14: 78.9: 11.93
+	Hs
		607883 MOES_HUMAN (1-583): 2.8e-161: 474: 80.96		FGFR4_HUMAN (535-810): 1.64e-14: 80.8: 15.79
+	Hs
		507865 MOES_HUMAN (1-583): 2.8e-161: 474: 80.96		FGFR1_HUMAN (2-160): 6.17e-14: 78.9: 11.93
+	Hs
		607900 MERL_HUMAN (2-583): 1.72e-151: 450: 45.30		FGFR4_HUMAN (535-810): 1.64e-14: 80.8: 15.79
+	Hs
		507884 MERL_HUMAN (2-583): 1.72e-151: 450: 45.30		FGFR1_HUMAN (2-160): 6.17e-14: 78.9: 11.93
+	Hs
		505551 EPB41_HUMAN (3-553): 1.19e-125: 392: 20.48		FGFR3_HUMAN (310-670): 4.9e-27: 121: 13.53
+	Mm
		1206834 E41L3_MOUSE (2-547): 1.36e-119: 377: 21.15		PTK7_MOUSE (2-154): 5.42e-17: 89.3: 13.55
+	Dm
		65329 MERH_DROME (3-583): 1.81e-130: 397: 40.26		OBSCN_DROME (133-251): 3.15e-10: 67.3: 15.45